Document Detail


Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes.
MedLine Citation:
PMID:  21800898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is commonly believed that nanomaterials cause nonspecific oxidative damage. Our mass spectrometry-based oxidative lipidomics analysis of all major phospholipid classes revealed highly selective patterns of pulmonary peroxidation after inhalation exposure of mice to single-walled carbon nanotubes. No oxidized molecular species were found in the two most abundant phospholipid classes: phosphatidylcholine and phosphatidylethanolamine. Peroxidation products were identified in three relatively minor classes of anionic phospholipids, cardiolipin, phosphatidylserine, and phosphatidylinositol, whereby oxygenation of polyunsaturated fatty acid residues also showed unusual substrate specificity. This nonrandom peroxidation coincided with the accumulation of apoptotic cells in the lung. A similar selective phospholipid peroxidation profile was detected upon incubation of a mixture of total lung lipids with H(2)O(2)/cytochrome c known to catalyze cardiolipin and phosphatidylserine peroxidation in apoptotic cells. The characterized specific phospholipid peroxidation signaling pathways indicate new approaches to the development of mitochondria-targeted regulators of cardiolipin peroxidation to protect against deleterious effects of pro-apoptotic effects of single-walled carbon nanotubes in the lung.
Authors:
Yulia Y Tyurina; Elena R Kisin; Ashley Murray; Vladimir A Tyurin; Valentina I Kapralova; Louis J Sparvero; Andrew A Amoscato; Alejandro K Samhan-Arias; Linda Swedin; Riitta Lahesmaa; Bengt Fadeel; Anna A Shvedova; Valerian E Kagan
Related Documents :
22653548 - Non-aqueous synthesis of isotropic and anisotropic actinide oxide nanocrystals.
22447938 - Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions i...
22234058 - Is there any link between oxidative stress and lung involvement due to inflammatory bow...
352308 - Dysmyelination revisited.
19321238 - Convenient synthesis and antimicrobial evaluation of some novel 2-substituted-3-methylb...
21175178 - Amplification of anti-diastereoselectivity via curtin-hammett effects in ruthenium-cata...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2011-08-04
Journal Detail:
Title:  ACS nano     Volume:  5     ISSN:  1936-086X     ISO Abbreviation:  ACS Nano     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-28     Completed Date:  2012-01-25     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  101313589     Medline TA:  ACS Nano     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7342-53     Citation Subset:  IM    
Copyright Information:
© 2011 American Chemical Society
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bronchoalveolar Lavage Fluid
Lipid Peroxidation*
Lipids / chemistry*
Lung / metabolism*
Mice
Mice, Inbred C57BL
Nanotubes, Carbon*
Phosphoproteins / chemistry*
Proteomics*
Grant Support
ID/Acronym/Agency:
HL094488/HL/NHLBI NIH HHS; HL70755/HL/NHLBI NIH HHS; OH008282/OH/NIOSH CDC HHS; R01 HL070755/HL/NHLBI NIH HHS; R01 HL070755-06/HL/NHLBI NIH HHS; R01 HL094488/HL/NHLBI NIH HHS; R01 HL094488-02/HL/NHLBI NIH HHS; U19 AI068021/AI/NIAID NIH HHS; U19 AI068021-07/AI/NIAID NIH HHS; U19AIO68021//PHS HHS
Chemical
Reg. No./Substance:
0/Lipids; 0/Nanotubes, Carbon; 0/Phosphoproteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Photonic Color Filters Integrated with Organic Solar Cells for Energy Harvesting.
Next Document:  Self-Contained Sequence Representation (SCSR): Bridging the Gap between Bioinformatics and Cheminfor...