| Global N-acetylaspartate declines even in benign multiple sclerosis. | |
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MedLine Citation:
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PMID: 20966065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Neuro-axonal damage is a well known sequelae of MS pathogeneses. Consequently, our aim was to test whether the ∼20% of patients with MS exhibiting a clinically benign disease course also have minimal neural dysfunction as reflected by the global concentration of their MR imaging marker NAA. MATERIALS AND METHODS: Q(NAA) was obtained with nonlocalizing whole-head (1)H-MR spectroscopy in 43 patients with benign RRMS (30 women, 13 men; mean age, 44.7 ± 7.3 years of age) with 21.0 ± 4.4 years (range, 15-35 years) of disease duration from the first symptom and an EDSS score of 1.9 (range, 0-3). Q(NAA) was by divided by the brain volume (from MR imaging segmentation) to normalize it into WBNAA. All participants gave institutional review board-approved written informed consent, and the study was HIPAA compliant. RESULTS: The patients' lesion load was 12.2 ± 7.7 cm(3). Their 8.3 ± 1.8 mmol/L WBNAA was 35% lower than that in controls (P < .001). Individual average loss rates (absolute loss compared with controls divided by disease duration) clustered around 0.22 ± 0.09 mmol/L/year (1.7%/year, assuming monotonic decline). This rate could be extrapolated from that already reported for patients with RRMS of much shorter disease duration. WBNAA did not correlate with lesion load or EDSS. CONCLUSIONS: Normal WBNAA is not characteristic of benign MS and is not an early predictor of its course. These patients, therefore, probably benefit from successful compensation and sparing of eloquent regions. Because they may ultimately have a rapid decline once their brain plasticity is exhausted, they may benefit from treatment options offered to more affected patients. |
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Authors:
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D J Rigotti; O Gonen; R I Grossman; J S Babb; A Falini; B Benedetti; M Filippi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-21 |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 32 ISSN: 1936-959X ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-14 Completed Date: 2011-05-10 Revised Date: 2011-12-13 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
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Languages: eng Pagination: 204-9 Citation Subset: IM |
Affiliation:
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Department of Radiology, New York University School of Medicine, New York, New York 10016, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aspartic Acid / analogs & derivatives*, metabolism Brain / metabolism* Down-Regulation Female Humans Magnetic Resonance Spectroscopy / methods* Male Multiple Sclerosis / metabolism* Protons / diagnostic use Tissue Distribution Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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EB01015/EB/NIBIB NIH HHS; NS0050520/NS/NINDS NIH HHS; NS39135/NS/NINDS NIH HHS; R01 EB001015-16/EB/NIBIB NIH HHS; R01 NS029029-20/NS/NINDS NIH HHS; R01 NS039135-10/NS/NINDS NIH HHS; R01 NS050520-05/NS/NINDS NIH HHS; R37 NS029029-15/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Protons; 56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate |
| Comments/Corrections | |
Comment In:
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AJNR Am J Neuroradiol. 2011 Jun-Jul;32(6):E118; author reply 119
[PMID:
21527568
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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