Document Detail


Global N-acetylaspartate declines even in benign multiple sclerosis.
MedLine Citation:
PMID:  20966065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Neuro-axonal damage is a well known sequelae of MS pathogeneses. Consequently, our aim was to test whether the ∼20% of patients with MS exhibiting a clinically benign disease course also have minimal neural dysfunction as reflected by the global concentration of their MR imaging marker NAA.
MATERIALS AND METHODS: Q(NAA) was obtained with nonlocalizing whole-head (1)H-MR spectroscopy in 43 patients with benign RRMS (30 women, 13 men; mean age, 44.7 ± 7.3 years of age) with 21.0 ± 4.4 years (range, 15-35 years) of disease duration from the first symptom and an EDSS score of 1.9 (range, 0-3). Q(NAA) was by divided by the brain volume (from MR imaging segmentation) to normalize it into WBNAA. All participants gave institutional review board-approved written informed consent, and the study was HIPAA compliant.
RESULTS: The patients' lesion load was 12.2 ± 7.7 cm(3). Their 8.3 ± 1.8 mmol/L WBNAA was 35% lower than that in controls (P < .001). Individual average loss rates (absolute loss compared with controls divided by disease duration) clustered around 0.22 ± 0.09 mmol/L/year (1.7%/year, assuming monotonic decline). This rate could be extrapolated from that already reported for patients with RRMS of much shorter disease duration. WBNAA did not correlate with lesion load or EDSS.
CONCLUSIONS: Normal WBNAA is not characteristic of benign MS and is not an early predictor of its course. These patients, therefore, probably benefit from successful compensation and sparing of eloquent regions. Because they may ultimately have a rapid decline once their brain plasticity is exhausted, they may benefit from treatment options offered to more affected patients.
Authors:
D J Rigotti; O Gonen; R I Grossman; J S Babb; A Falini; B Benedetti; M Filippi
Related Documents :
10540005 - Acoustic analysis of dysarthria profile in als patients.
16944115 - Loss of interhemispheric inhibition in patients with multiple sclerosis is related to c...
1436535 - Aphasia in multiple sclerosis: clinical and radiologic correlations.
15102255 - Transdermal fentanyl: little absorption in two patients with systemic sclerosis?
8871835 - Cardiac manifestations in dermato-polymyositis.
22502785 - Decompressive craniectomy after intravenous tissue plasminogen activator administration...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-21
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  32     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-14     Completed Date:  2011-05-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM    
Affiliation:
Department of Radiology, New York University School of Medicine, New York, New York 10016, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aspartic Acid / analogs & derivatives*,  metabolism
Brain / metabolism*
Down-Regulation
Female
Humans
Magnetic Resonance Spectroscopy / methods*
Male
Multiple Sclerosis / metabolism*
Protons / diagnostic use
Tissue Distribution
Young Adult
Grant Support
ID/Acronym/Agency:
EB01015/EB/NIBIB NIH HHS; NS0050520/NS/NINDS NIH HHS; NS39135/NS/NINDS NIH HHS; R01 EB001015-16/EB/NIBIB NIH HHS; R01 NS029029-20/NS/NINDS NIH HHS; R01 NS039135-10/NS/NINDS NIH HHS; R01 NS050520-05/NS/NINDS NIH HHS; R37 NS029029-15/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Protons; 56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate
Comments/Corrections
Comment In:
AJNR Am J Neuroradiol. 2011 Jun-Jul;32(6):E118; author reply 119   [PMID:  21527568 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cerebral microhemorrhages detected by susceptibility-weighted imaging in amateur boxers.
Next Document:  Treatment of brain arteriovenous malformations by double arterial catheterization with simultaneous ...