Document Detail


Glioblastoma with granular cell astrocytoma features: a case report and literature review.
MedLine Citation:
PMID:  20860896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present the case of a 69-year old patient with a contrast enhancing, partially cystic lesion of the right temporal lobe, involving the ventricle and extending into the occipital lobe. The resected tumor showed histological features of a glioblastoma with granular cell astrocytoma features, lacking amplification of the EGFR gene region and IDH1R132H mutation. Literature review of 59 cases showed a 12-month overall survival of 11.7% for high-grade and 40% for low-grade granular cell astrocytomas. In 35% more than one cerebral lobe was affected. These extended mass effects may explain the worse prognosis despite the relatively bland histology of the granular cell component.
Authors:
J Schittenhelm; T Psaras
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical neuropathology     Volume:  29     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-09-23     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  323-9     Citation Subset:  IM    
Affiliation:
Institute of Brain Research, University Hospital, Eberhard Karls University of Tuebingen, Germany. jens.schittenhelm@med.uni-tuebingen.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Astrocytoma / diagnosis,  pathology*
Brain Neoplasms / diagnosis,  pathology*
Female
Glioblastoma / diagnosis,  pathology*
Humans
Temporal Lobe / pathology

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