Document Detail

Glioblastoma multiforme: radiologic-pathologic correlation.
MedLine Citation:
PMID:  8946545     Owner:  NLM     Status:  MEDLINE    
Astrocytic tumors are divided into two basic categories: circumscribed (grade I) or diffuse (grades II-IV). All diffuse astrocytomas tend to progress to grade IV astrocytoma, which is synonymous with glioblastoma multiforme (GBM). GBMs are characterized by marked neovascularity, increased mitosis, greater degree of cellularity and nuclear pleomorphism, and microscopic evidence of necrosis. Several genetic abnormalities have been associated with the development of GBM: In some cases, the abnormality is inherited (e.g., Li-Fraumeni syndrome); in others, genetic alteration appears to result from mutation into an oncogene or deterioration of the tumor-suppressor gene p53. A common, distinctive histopathologic feature of GBM is pseudopalisading. The most common imaging appearance of GBM is a large heterogeneous mass in the supratentorial white matter that exerts considerable mass effect. Less frequently, GBM can occur near the dura mater or in the corpus callosum, posterior fossa, and spinal cord. GBM typically contains central areas of necrosis, has thick irregular walls, and is surrounded by extensive, vasogenic edema, but the tumor may also have thin round walls, scant edema, or a cystic appearance with a mural nodule. GBMs most commonly metastasize from their original location by direct extension along white matter tracts; however, cerebrospinal fluid, subependymal, and hematogenous spread also can occur. Given the rapidly growing body of knowledge about GBM, the radiologist's role is more important than ever in accurate and timely diagnosis.
J H Rees; J G Smirniotopoulos; R V Jones; K Wong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiographics : a review publication of the Radiological Society of North America, Inc     Volume:  16     ISSN:  0271-5333     ISO Abbreviation:  Radiographics     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-28     Completed Date:  1997-02-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302501     Medline TA:  Radiographics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1413-38; quiz 1462-3     Citation Subset:  IM    
Department of Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA.
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MeSH Terms
Brain / pathology,  radiography
Brain Neoplasms / diagnosis,  pathology,  radiography*
Glioblastoma / diagnosis,  pathology,  radiography*
Magnetic Resonance Imaging
Spinal Cord Neoplasms / diagnosis,  radiography
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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