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Glioblastoma mimicking herpes simplex encephalitis.
MedLine Citation:
PMID:  22053231     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
We report a case of 70-year-old man with glioblastoma presenting as acute encephalitic illness. The patient exhibited sudden onset of cognitive impairment and headache for 2 days. Initial brain MRI showed left temporal lobe hyperintensity, and cerebrospinal fluid cytology revealed a mild pleocytosis. The patient had initially improved after medical treatment with a presumptive diagnosis of herpes simplex encephalitis (HSE). After 8 months, the patient complained of recurrent seizures. A follow-up brain MRI revealed marked increases in size and surrounding perilesional edema in the left temporal lesion on T2-weighted images and a new contrast-enhancing lesion on gadolinium-enhanced T1-weighted images. Stereotactic brain biopsy revealed a glioblastoma. The atypical encephalitic presentation of glioblastoma should be considered if definitive evidence for the diagnosis of HSE cannot be obtained.
Authors:
Tai-Seung Nam; Kang-Ho Choi; Myeong-Kyu Kim; Ki-Hyun Cho
Publication Detail:
Type:  Journal Article     Date:  2011-08-31
Journal Detail:
Title:  Journal of Korean Neurosurgical Society     Volume:  50     ISSN:  1598-7876     ISO Abbreviation:  J Korean Neurosurg Soc     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-11-04     Completed Date:  2011-11-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101467054     Medline TA:  J Korean Neurosurg Soc     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  -    
Affiliation:
Department of Neurology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
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