Document Detail


Glioblastoma of the cerebellum and brainstem.
MedLine Citation:
PMID:  20619657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glioblastoma multiforme (GB) is the most common and most malignant primary intracranial tumor. Of the 577 patients who underwent surgery for newly diagnosed GB (World Health Organization grade IV) between January 1991 and March 2008 at our department, seven had infratentorial GB (iGB) (incidence 1.2%). Patients younger than 21years of age, as well as patients with gliomatosis cerebri, were excluded from the analysis. We concluded that iGB is rare in adults. Because of its rarity and the non-specific radiological features of iGB, it can easily be misdiagnosed as a brain metastasis, ependymoma or even as a benign lesion such as vestibular schwannoma or meningioma. Surgical removal, or at least stereotactic biopsy, is essential to establish the diagnosis. Postoperative adjuvant therapy similar to that for supratentorial glioblastoma is indicated. We analysed the clinical characteristics and therapy of our patients with iGB and reviewed the literature.
Authors:
Andreas Martin Stark; Homajoun Maslehaty; Heinz Hermann Hugo; Mehran Mahvash; Hubertus Maximilian Mehdorn
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Publication Detail:
Type:  Journal Article     Date:  2010-07-08
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  17     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  1248-51     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Neurosurgery, University of Kiel, Arnold Heller Strasse 3, Kiel 24105, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Brain Neoplasms / pathology*,  surgery
Brain Stem / pathology*,  surgery
Cerebellum / pathology*,  surgery
Female
Glioblastoma / pathology*,  surgery
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Retrospective Studies
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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