| Glioblastoma cancer stem cells: heterogeneity, microenvironment and related therapeutic strategies. | |
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MedLine Citation:
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PMID: 20535838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glioblastoma Multiforme (GBM) is an incurable malignancy. GBM patients have a short life expectancy despite aggressive therapeutic approaches based on surgical resection followed by adjuvant radiotherapy and concomitant chemotherapy. Glioblastoma growth is characterized by a high motility of tumour cells, their resistance to both chemo/radio-therapy, apoptosis inhibition leading to failure of conventional therapy. Cancer Stem Cells (CSCs), identified in GBM as well as in many other cancer types, express the membrane antigen prominin-1 (namely CD133). These cells and normal Neural Stem Cells (NSC) share surface markers and properties, i.e. are able to self-renew and differentiate into multiple cell types. Stem cell self-renewal depends on microenvironmental cues, including Extracellular Matrix (ECM) composition and cell types. Therefore, the role of microenvironment needs to be evaluated to clarify its importance in tumour initiation and progression through CSCs. The specific microenvironment of CSCs was found to mimic in part the vascular niche of normal stem cells. The targeting of GMB CSCs may represent a powerful treatment approach. Lastly, in GBM patients cancer-initiating cells contribute to the profound immune suppression that in turn correlated with CSCs STAT3 (CD133 + ). Further studies of microenvironment are needed to better understand the origin of GMB/GBM CSCs and its immunosuppressive properties. |
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Authors:
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Tetyana Denysenko; Luisa Gennero; Maria Augusta Roos; Antonio Melcarne; Carola Juenemann; Giuliano Faccani; Isabella Morra; Giovanni Cavallo; Stefano Reguzzi; Gianpiero Pescarmona; Antonio Ponzetto |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cell biochemistry and function Volume: 28 ISSN: 1099-0844 ISO Abbreviation: Cell Biochem. Funct. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8305874 Medline TA: Cell Biochem Funct Country: England |
Other Details:
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Languages: eng Pagination: 343-51 Citation Subset: IM |
Copyright Information:
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Copyright 2010 John Wiley & Sons, Ltd. |
Affiliation:
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CeRMS, Center for Experimental Research and Medical Studies, Turin, Italy. de_tanya@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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metabolism Combined Modality Therapy Drug Resistance, Neoplasm Glioblastoma / immunology, therapy* Glycoproteins / metabolism Humans Neoplastic Stem Cells / cytology, metabolism* Peptides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/AC133 antigen; 0/Antigens, CD; 0/Glycoproteins; 0/Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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