Document Detail

Glibenclamide-sensitive hypotension produced by helodermin assessed in the rat.
MedLine Citation:
PMID:  9881641     Owner:  NLM     Status:  MEDLINE    
The effects of helodermin, a basic 35-amino acid peptide isolated from the venom of a lizard salivary gland, on arterial blood pressure and heart rate were examined in the rat, focusing on the possibility that activation of ATP sensitive K+ (K(ATP)) channels is involved in the responses. The results were also compared with those of vasoactive intestinal polypeptide (VIP). Helodermin produced hypotension in a dose-dependent manner with approximately similar potency and duration to VIP. Hypotension induced by both peptides was significantly attenuated by glibenclamide, which abolished a levcromakalim-produced decrease in arterial blood pressure. Oxyhemoglobin did not affect helodermin-induced hypotension, whereas it shortened the duration of acetylcholine (ACh)-produced hypotension. These findings suggest that helodermin-produced hypotension is partly attributable to the activation of glibenclamide-sensitive K+ channels (K(ATP) channels), which presumably exist on arterial smooth muscle cells. EDRF (endothelium-derived relaxing factor)/nitric oxide does not seem to play an important role in the peptide-produced hypotension.
N Horikawa; K Kataha; N Watanabe; K Ishii; N Yanaihara; Y Tanaka; K Shigenobu; K Nakayama
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  21     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-23     Completed Date:  1999-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1290-3     Citation Subset:  IM    
Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
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MeSH Terms
Blood Pressure / drug effects*
Glyburide / pharmacology
Heart Rate / drug effects*
Hypotension / chemically induced
Oxyhemoglobins / pharmacology
Peptides / pharmacology*
Potassium Channels / drug effects
Rats, Wistar
Vasoactive Intestinal Peptide / pharmacology
Reg. No./Substance:
0/Oxyhemoglobins; 0/Peptides; 0/Potassium Channels; 10238-21-8/Glyburide; 37221-79-7/Vasoactive Intestinal Peptide; 89468-62-2/heliodermin

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