| Glial and neuronal localization of ionotropic glutamate receptor subunit-immunoreactivities in the median eminence of female rats: GluR2/3 and GluR6/7 colocalize with vimentin, not with glial fibrillary acidic protein (GFAP). | |
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MedLine Citation:
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PMID: 10700615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Female rat median eminence was immunostained with anti-NR1, GluR1, GluR2/3, GluR6/7, or KA2. GluR2/3- and GluR6/7-immunoreactivities were detected in cells lining the basal portion of the third ventricle. To identify these cells as tanycytes, the median eminence was dual-immunostained with glutamate receptors and glial cytoskeletal marker proteins, such as vimentin or glial fibrillary acidic protein (GFAP). Both GluR2/3 and GluR6/7 were shown to colocalize with vimentin, not with GFAP. These results suggest the potential role for tanycytes in conducting glutamate signaling. |
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Authors:
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S Kawakami |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 858 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-04-25 Completed Date: 2000-04-25 Revised Date: 2010-01-13 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 198-204 Citation Subset: IM |
Affiliation:
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School of Agricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan. skawak@knaes.affrc.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / cytology, metabolism Female Glial Fibrillary Acidic Protein / metabolism* Immunohistochemistry Median Eminence / metabolism*, ultrastructure Neuroglia / cytology, metabolism* Neurons / cytology, metabolism* RNA, Messenger / metabolism Rats Rats, Wistar Receptors, AMPA / metabolism Receptors, Glutamate / metabolism* Receptors, Kainic Acid / metabolism Vimentin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Glial Fibrillary Acidic Protein; 0/GluK3 kainate receptor; 0/Gluk2 kainate receptor; 0/RNA, Messenger; 0/Receptors, AMPA; 0/Receptors, Glutamate; 0/Receptors, Kainic Acid; 0/Vimentin; 0/glutamate receptor ionotropic, AMPA 1; 0/glutamate receptor ionotropic, AMPA 2; 0/glutamate receptor ionotropic, AMPA 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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