Document Detail


Glial and neuronal localization of ionotropic glutamate receptor subunit-immunoreactivities in the median eminence of female rats: GluR2/3 and GluR6/7 colocalize with vimentin, not with glial fibrillary acidic protein (GFAP).
MedLine Citation:
PMID:  10700615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Female rat median eminence was immunostained with anti-NR1, GluR1, GluR2/3, GluR6/7, or KA2. GluR2/3- and GluR6/7-immunoreactivities were detected in cells lining the basal portion of the third ventricle. To identify these cells as tanycytes, the median eminence was dual-immunostained with glutamate receptors and glial cytoskeletal marker proteins, such as vimentin or glial fibrillary acidic protein (GFAP). Both GluR2/3 and GluR6/7 were shown to colocalize with vimentin, not with GFAP. These results suggest the potential role for tanycytes in conducting glutamate signaling.
Authors:
S Kawakami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  858     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-25     Completed Date:  2000-04-25     Revised Date:  2010-01-13    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  198-204     Citation Subset:  IM    
Affiliation:
School of Agricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan. skawak@knaes.affrc.go.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / cytology,  metabolism
Female
Glial Fibrillary Acidic Protein / metabolism*
Immunohistochemistry
Median Eminence / metabolism*,  ultrastructure
Neuroglia / cytology,  metabolism*
Neurons / cytology,  metabolism*
RNA, Messenger / metabolism
Rats
Rats, Wistar
Receptors, AMPA / metabolism
Receptors, Glutamate / metabolism*
Receptors, Kainic Acid / metabolism
Vimentin / metabolism*
Chemical
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; 0/GluK3 kainate receptor; 0/Gluk2 kainate receptor; 0/RNA, Messenger; 0/Receptors, AMPA; 0/Receptors, Glutamate; 0/Receptors, Kainic Acid; 0/Vimentin; 0/glutamate receptor ionotropic, AMPA 1; 0/glutamate receptor ionotropic, AMPA 2; 0/glutamate receptor ionotropic, AMPA 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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