| Glial and neuronal control of brain blood flow. | |
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MedLine Citation:
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PMID: 21068832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches. |
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Authors:
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David Attwell; Alastair M Buchan; Serge Charpak; Martin Lauritzen; Brian A Macvicar; Eric A Newman |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature Volume: 468 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-11 Completed Date: 2010-12-23 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 232-43 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. d.attwell@ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism,
pathology,
physiopathology Brain / blood supply* Brain Ischemia / metabolism, pathology, physiopathology Cerebrovascular Circulation / physiology* Humans Neuroglia / physiology* Neurons / physiology* Neurotransmitter Agents / metabolism Nitric Oxide / metabolism Oxygen / metabolism Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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//Canadian Institutes of Health Research; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents; 10102-43-9/Nitric Oxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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