Document Detail


Glial heterotopia of the uterine cervix: DNA genotyping confirmation of its fetal origin.
MedLine Citation:
PMID:  20567155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uterine glial heterotopia is a rare, yet biologically intriguing lesion, mostly involving the cervix. Although an implantation of the fetal brain tissue is widely accepted as the etiology, there has been no confirming evidence to support this hypothesis. We investigated a case of polypoid glial heterotopia of the uterine cervix in a 42-year-old woman who underwent an elective termination of pregnancy of a Down syndrome fetus. One year earlier, the patient had a pregnancy termination of a fetus with Klinefelter's syndrome. Gross and microscopic examination revealed a 2.5 cm polypoid cervical lesion consisting of lobulated mature glial tissue covered by endocervical glandular epithelium. The neural nature of the lesion was confirmed by glial fibrillary acidic protein and S100 immunohistochemistry. DNA genotyping of the cervical polyp, maternal, first and second fetal tissue samples showed an identical genetic profile between the cervical glial tissue and the first aborted fetus. Genotyping also attested the presence of Klinefelter's syndrome in the first gestation and Down syndrome in the second gestation. Therefore, this molecular case investigation confirms the fetal origin of uterine glial heterotopia.
Authors:
Alexa Siddon; Pei Hui
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  29     ISSN:  1538-7151     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  394-7     Citation Subset:  IM    
Affiliation:
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023, USA.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Induced
Adult
DNA, Neoplasm / chemistry,  genetics
Female
Fetus
Genotype
Glial Fibrillary Acidic Protein / analysis,  genetics,  metabolism*
Humans
Immunohistochemistry
Microsatellite Repeats / genetics
Polymerase Chain Reaction
Pregnancy
S100 Proteins / analysis,  metabolism*
Uterine Cervical Neoplasms / metabolism,  pathology*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Glial Fibrillary Acidic Protein; 0/S100 Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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