| Glial fibrillary acidic protein in the cerebrospinal fluid of children with autism and other neuropsychiatric disorders. | |
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MedLine Citation:
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PMID: 8353169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cerebrospinal fluid (CSF) of 47 children and adolescents with autism was analyzed for the contents of two astroglial proteins, the glial fibrillary acidic protein (GFA) and S 100. The results were contrasted with those obtained in similarly aged cases with other neuropsychiatric disorders (n = 25) and in normal children (n = 10). S-100 did not discriminate the groups from each other. However, GFA in autism and autistic-like conditions was at a level almost three times that in the normal group. The results could implicate gliosis and unspecific brain damage in autism. An alternative model would be increased synapse turnover regardless of underlying cause. |
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Authors:
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G Ahlsén; L Rosengren; M Belfrage; A Palm; K Haglid; A Hamberger; C Gillberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological psychiatry Volume: 33 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-09-22 Completed Date: 1993-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 734-43 Citation Subset: IM |
Affiliation:
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Department of Child Neuropsychiatry, University of Göteborg, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Autistic Disorder / cerebrospinal fluid*, diagnosis, psychology Basal Ganglia Diseases / cerebrospinal fluid, diagnosis, psychology Brain Damage, Chronic / cerebrospinal fluid*, diagnosis, psychology Child Child, Preschool Delirium, Dementia, Amnestic, Cognitive Disorders / cerebrospinal fluid*, diagnosis, psychology Female Glial Fibrillary Acidic Protein / cerebrospinal fluid* Humans Infant Language Development Disorders / cerebrospinal fluid, diagnosis, psychology Male Phosphopyruvate Hydratase / cerebrospinal fluid Reference Values Rett Syndrome / cerebrospinal fluid, diagnosis, psychology S100 Proteins / cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
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0/Glial Fibrillary Acidic Protein; 0/S100 Proteins; EC 4.2.1.11/Phosphopyruvate Hydratase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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