Document Detail

Glial fibrillary acidic protein (GFAP)-immunoreactivity is reduced by castration in the interpeduncular nucleus of male rats.
MedLine Citation:
PMID:  10439439     Owner:  NLM     Status:  MEDLINE    
The interpeduncular nucleus of adult male rats was investigated for glial fibrillary acidic protein immunoreactivity. In intact animals the nucleus had an outstandingly intense immunostaining, particularly at its periphery, including the rostral, lateral, dorsomedial and dorsolateral subnuclei where, in addition to neuropil astrocytes, a substantial amount of perivascualr glia was found. Four weeks after castration, immunostaining decreased markedly in the core region of the nucleus corresponding to the caudal and medial subnuclei, and to a much lesser extent at the periphery. The immunoreactivity in pericapillary astrocytes proved to be insensitive to castration. Testosterone, if administered after castration prevented or restituted the loss of immunoreactivity. Beyond 4 months after castration, the effect of testosterone gradually declined. It is concluded that testosterone stimulates the expression of glial fibrillary acidic protein immunoreactivity in the interpeduncular nucleus. Our findings support the argument that gonadal steroids can influence astrocytes also in non-endocrine areas of the brain.
F Hajós; K Halasy; B Gerics; F Szalay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  10     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-30     Completed Date:  1999-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2229-33     Citation Subset:  IM    
Department of Anatomy and Histology, University of Veterinary Science, Budapest, Hungary.
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MeSH Terms
Cell Nucleus / metabolism
Glial Fibrillary Acidic Protein / metabolism*
Limbic System / drug effects,  metabolism*
Rats, Wistar
Testosterone / pharmacology
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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