Document Detail

Glial fatty metamorphosis. An abnormal response of premyelin glia frequently accompanying periventricular leukomalacia.
MedLine Citation:
PMID:  4814904     Owner:  NLM     Status:  MEDLINE    
Within the developing nervous system, there is a complex relationship between the accumulation of sudanophilic lipids in glial cells and gestational and postnatal age. Sudanophilic lipids accumulate to a small degree as a stage of normal premyelin lipogenesis, but large amounts of such accumulations may be considered abnormal. The dividing line between the normal and the abnormal (glial fatty metamorphosis) must be defined for each region of the nervous system, since the time and rate of myelination vary widely. Examination of the brains of premature infants routinely coming to autopsy utilizing the oil red O technic on gelatin-embedded frozen sections has allowed this definition to be made in at least some situations. Glial fatty metamorphosis is characterized by an absolute increase in the amount of lipid droplets in the glial precursor cells and by an absolute increase in the ratio of lipid-containing cells to the total cell population. It is more easily recognized in the corpus callosum in cases of periventricular leukomalacia, but may occur in other disease states, and appears to represent a response of metabolically active immature glial cells to metabolic stress (hypoxia-acidosis).
R W Leech; E C Alvord
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  74     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1974 Mar 
Date Detail:
Created Date:  1974-04-29     Completed Date:  1974-04-29     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  603-12     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Brain / metabolism,  pathology*
Brain Diseases / congenital*,  metabolism,  pathology
Corpus Callosum / pathology
Gestational Age
Hypoxia, Brain / congenital*,  metabolism,  pathology
Infant, Newborn
Infant, Newborn, Diseases / metabolism,  pathology*
Lipid Metabolism
Neuroglia / metabolism*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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