Document Detail


Glial expression of presenilin epitopes in human brain with cerebral infarction and in astrocytoma.
MedLine Citation:
PMID:  10502036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Presenilins, some gene mutations of which are associated with familial Alzheimer's disease (AD), are expressed mainly in neurons in normal brains and brains from patients clinicopathologically diagnosed as AD. They are thought to be related to cell death and survival. We studied the immunolocalization of presenilin to investigate its possible relation to cell death and glial proliferation, using two antibodies against different portions of the presenilin 1 protein, in human brains with cerebral infarction and in astrocytoma, where abundant cell death and glial proliferation are present. Expression of presenilin epitopes was more marked in glial cells than in neurons in and around the ischemic focus, and it was also robust in astrocytoma cells. These findings suggest that presenilins are functioning not only in neurons but also in glial cells in reactive and neoplastic proliferation.
Authors:
H Miake; K Tsuchiya; A Nakamura; K Ikeda; L Levesque; P E Fraser; P H St-George Hyslop; H Mizusawa; T Uchihara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neuropathologica     Volume:  98     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-05     Completed Date:  1999-11-05     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  337-40     Citation Subset:  IM    
Affiliation:
Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashi-dai, Fuchu, Tokyo 183-8526, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Astrocytoma / metabolism*
Brain Chemistry / genetics,  physiology*
Brain Ischemia / metabolism
Brain Neoplasms / metabolism*
Cerebral Infarction / metabolism*
Epitopes / biosynthesis,  genetics
Female
Glial Fibrillary Acidic Protein / metabolism
Humans
Immunoglobulin G / immunology
Male
Membrane Proteins / biosynthesis*,  genetics
Middle Aged
Neuroglia / physiology*
Paraffin Embedding
Presenilin-2
Chemical
Reg. No./Substance:
0/Epitopes; 0/Glial Fibrillary Acidic Protein; 0/Immunoglobulin G; 0/Membrane Proteins; 0/PSEN2 protein, human; 0/Presenilin-2

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