Document Detail

Glial cells: old cells with new twists.
MedLine Citation:
PMID:  18068219     Owner:  NLM     Status:  MEDLINE    
Based on their characteristics and function--migration, neural protection, proliferation, axonal guidance and trophic effects--glial cells may be regarded as probably the most versatile cells in our body. For many years, these cells were considered as simply support cells for neurons. Recently, it has been shown that they are more versatile than previously believed--as true stem cells in the nervous system--and are important players in neural function and development. There are several glial cell types in the nervous system: the two most abundant are oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. Although both of these cells are responsible for myelination, their developmental origins are quite different. Oligodendrocytes originate from small niche populations from different regions of the central nervous system, while Schwann cells develop from a stem cell population (the neural crest) that gives rise to many cell derivatives besides glia and which is a highly migratory group of cells.
Ugo Ndubaku; Maria Elena de Bellard
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-12-18
Journal Detail:
Title:  Acta histochemica     Volume:  110     ISSN:  0065-1281     ISO Abbreviation:  Acta Histochem.     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-25     Completed Date:  2008-08-08     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  182-95     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation / physiology
Central Nervous System / cytology,  physiology
Neural Crest / cytology,  embryology,  physiology
Neuroglia / cytology*,  physiology
Oligodendroglia / cytology*,  physiology
Peripheral Nervous System / cytology,  physiology
Schwann Cells / cytology*,  physiology
Stem Cells / cytology,  physiology
Grant Support
R15 NS060099/NS/NINDS NIH HHS; R15 NS060099-01/NS/NINDS NIH HHS; S06 GM048680/GM/NIGMS NIH HHS; S06 GM048680-12A10018/GM/NIGMS NIH HHS; SC3 GM096904/GM/NIGMS NIH HHS

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