Document Detail


Glia and methylmercury neurotoxicity.
MedLine Citation:
PMID:  22852858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methylmercury (MeHg) is a global environmental pollutant with significant adverse effects on human health. As the major target of MeHg, the central nervous system (CNS) exhibits the most recognizable poisoning symptoms. The role of the two major nonneuronal cell types, astrocytes and microglia, in response to MeHg exposure was recently compared. These two cell types share several common features in MeHg toxicity, but interestingly, these cells types also exhibit distinct response kinetics, indicating a cell-specific role in mediating MeHg-induced neurotoxicity. The aim of this study was to review the most recent literature and summarize key features of glial responses to this organometal.
Authors:
Mingwei Ni; Xin Li; João B T Rocha; Marcelo Farina; Michael Aschner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part A     Volume:  75     ISSN:  1528-7394     ISO Abbreviation:  J. Toxicol. Environ. Health Part A     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-02     Completed Date:  2012-10-09     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  100960995     Medline TA:  J Toxicol Environ Health A     Country:  England    
Other Details:
Languages:  eng     Pagination:  1091-101     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Astrocytes / drug effects*
Environmental Pollutants / toxicity*
Humans
Methylmercury Compounds / toxicity*
Microglia / drug effects*
Grant Support
ID/Acronym/Agency:
P30ES00267/ES/NIEHS NIH HHS; R01ES07331/ES/NIEHS NIH HHS; T32 GM007628/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Methylmercury Compounds
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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