Document Detail

Glaucoma screening in a high-risk population.
MedLine Citation:
PMID:  17106368     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate a screening protocol for detection of individuals with a higher risk of chronic open angle glaucoma for which a complete glaucoma evaluation is indicated. PATIENTS AND METHODS: African Americans over 40 years of age in New Haven, CT. In the screening phase, volunteers filled out a questionnaire and underwent measurements of visual acuity, intraocular pressure (IOP) with a Tono-Pen and visual field with Frequency Doubling Technology. Participants were categorized into "glaucoma likely" or "unlikely," but all were encouraged to follow up with a free complete glaucoma exam, which included applanation tonometry, pachymetry, visual fields with a Humphrey Visual Field Analyzer, gonioscopy, and fundoscopy. Based on the latter exam, patients were categorized into "glaucoma likely" (suspects and confirmed glaucoma) or "unlikely" groups. RESULTS: One hundred eighty-four subjects completed both phases of the study and 76 of 93 patients (82%) who were classified as "glaucoma likely" in the final exam, were also classified as "glaucoma likely" in the screening. Adjusted analysis revealed family history of glaucoma in first degree relatives and screening IOP > 21 mm Hg to have statistically significant associations with the final impression of "glaucoma likely." A combination of these findings gave an overall sensitivity of 81.7% with a specificity of 55%. CONCLUSIONS: In the study population, the combination of an IOP > 21 mm Hg and history of glaucoma in a first degree relative allowed the identification of a significant percentage of individuals with a higher risk of chronic open angle glaucoma, for which a complete glaucoma examination is indicated.
Setareh Vistamehr; Heather N Shelsta; Philip C Palmisano; Giovanni Filardo; Kent Bashford; Kamran Chaudhri; Susan H Forster; George Shafranov; M Bruce Shields
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of glaucoma     Volume:  15     ISSN:  1057-0829     ISO Abbreviation:  J. Glaucoma     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-19     Completed Date:  2006-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  534-40     Citation Subset:  IM    
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA.
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MeSH Terms
African Americans*
Aged, 80 and over
Chronic Disease
Glaucoma, Open-Angle / diagnosis*,  ethnology*
Intraocular Pressure
Mass Screening / methods*
Middle Aged
Optic Disk / pathology
Optic Nerve Diseases / diagnosis,  ethnology
Risk Factors
Sensitivity and Specificity
Tonometry, Ocular
Vision Disorders / diagnosis,  ethnology
Visual Acuity
Visual Fields

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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