Document Detail


Glaucoma: changes in extracellular matrix in the optic nerve head.
MedLine Citation:
PMID:  8217094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary open angle glaucoma (POAG), the most common form of glaucoma, is characterized by irreversible loss of axons from the optic nerve. The site of damage to the axons is at the level of the lamina cribrosa in the optic nerve head. It has been hypothesized that structural and biochemical abnormalities in the extracellular matrix (ECM) of the lamina cribrosa underlie the progressive compressive and remodelling of this connective tissue in glaucoma. In this review, we present evidence of specific changes in collagen and elastic fibers, major ECM components in the lamina cribrosa of glaucomatous eyes.
Authors:
M R Hernandez; H Ye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annals of medicine     Volume:  25     ISSN:  0785-3890     ISO Abbreviation:  Ann. Med.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-03     Completed Date:  1993-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  309-15     Citation Subset:  IM    
Affiliation:
Schepens Eye Research Institute, Boston, MA 02114.
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MeSH Terms
Descriptor/Qualifier:
Collagen / ultrastructure
Elastin / ultrastructure
Extracellular Matrix / ultrastructure*
Fluorescent Antibody Technique
Glaucoma, Open-Angle / pathology*
Glial Fibrillary Acidic Protein / ultrastructure
Humans
Microscopy, Immunoelectron
Optic Disk / ultrastructure*
Optic Nerve / ultrastructure
Grant Support
ID/Acronym/Agency:
NEI EYO6416/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; 9007-34-5/Collagen; 9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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