| Glaucoma: changes in extracellular matrix in the optic nerve head. | |
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MedLine Citation:
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PMID: 8217094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary open angle glaucoma (POAG), the most common form of glaucoma, is characterized by irreversible loss of axons from the optic nerve. The site of damage to the axons is at the level of the lamina cribrosa in the optic nerve head. It has been hypothesized that structural and biochemical abnormalities in the extracellular matrix (ECM) of the lamina cribrosa underlie the progressive compressive and remodelling of this connective tissue in glaucoma. In this review, we present evidence of specific changes in collagen and elastic fibers, major ECM components in the lamina cribrosa of glaucomatous eyes. |
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Authors:
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M R Hernandez; H Ye |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Annals of medicine Volume: 25 ISSN: 0785-3890 ISO Abbreviation: Ann. Med. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-12-03 Completed Date: 1993-12-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8906388 Medline TA: Ann Med Country: FINLAND |
Other Details:
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Languages: eng Pagination: 309-15 Citation Subset: IM |
Affiliation:
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Schepens Eye Research Institute, Boston, MA 02114. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Collagen
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ultrastructure Elastin / ultrastructure Extracellular Matrix / ultrastructure* Fluorescent Antibody Technique Glaucoma, Open-Angle / pathology* Glial Fibrillary Acidic Protein / ultrastructure Humans Microscopy, Immunoelectron Optic Disk / ultrastructure* Optic Nerve / ultrastructure |
| Grant Support | |
ID/Acronym/Agency:
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NEI EYO6416/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glial Fibrillary Acidic Protein; 9007-34-5/Collagen; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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