Document Detail

Glaucoma filtration surgery following sustained elevation of intraocular pressure secondary to intravitreal anti-VEGF injections.
MedLine Citation:
PMID:  22788585     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: To document cases of sustained elevation of intraocular pressure (IOP) while receiving intravitreal anti-vascular endothelial growth factor (VEGF) agents and subsequent management.
PATIENTS AND METHODS: A retrospective series of all cases managed by the authors and colleagues was performed.
RESULTS: Six patients developed sustained elevated IOP; five received ranibizumab and one bevacizumab. Four received unilateral and two received bilateral injections. Two had preexisting primary open-angle glaucoma and one had pseudoexfoliative glaucoma, all with stable IOP prior to anti-VEGF treatment. Angles were open in all cases. Peak IOP averaged 43 mm Hg (range: 34 to 60 mm Hg). The mean number of injections preceding the IOP increase was 10 (range: 1 to 20). Four patients required trabeculectomy, one selective laser trabeculoplasty, and one multiple topical medications.
CONCLUSION: A sustained increase in IOP requiring glaucoma filtering surgery is a rare but important treatment complication for patients receiving intravitreal anti-VEGF therapy, especially those with preexisting glaucoma or glaucoma risk factors.
Simon E Skalicky; Ivan Ho; Ashish Agar; Allan Bank
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye     Volume:  43     ISSN:  1938-2375     ISO Abbreviation:  Ophthalmic Surg Lasers Imaging     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-13     Completed Date:  2012-10-12     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  101155780     Medline TA:  Ophthalmic Surg Lasers Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  328-34     Citation Subset:  IM    
Copyright Information:
Copyright 2012, SLACK Incorporated.
Sydney Eye Hospital, University of Sydney, Australia.
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MeSH Terms
Aged, 80 and over
Angiogenesis Inhibitors / administration & dosage,  adverse effects*
Antibodies, Monoclonal, Humanized / administration & dosage,  adverse effects
Antihypertensive Agents / therapeutic use
Choroidal Neovascularization / drug therapy
Glaucoma, Open-Angle / complications
Intraocular Pressure / drug effects*
Intravitreal Injections
Macular Degeneration / drug therapy
Middle Aged
Ocular Hypertension / chemically induced,  surgery*
Retrospective Studies
Vascular Endothelial Growth Factor A / antagonists & inhibitors
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 0/Antihypertensive Agents; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 0/ranibizumab; 2S9ZZM9Q9V/bevacizumab

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