Document Detail


Glatiramer acetate exposure in pregnancy: preliminary safety and birth outcomes.
MedLine Citation:
PMID:  20625758     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
With the increasing incidence of multiple sclerosis (MS) in women and the earlier use of disease modifying therapy (DMT), issues surrounding DMT and pregnancy are a regular subject of discussion with regards to optimal management. Current recommendations are to withdraw DMT prior to conception, leaving patients exposed to an uncertain period of untreated disease. The objective of this study is to report preliminary experience on glatiramer acetate (GA) exposure through conception, pregnancy and the post-partum period in a series of 13 patients with previously highly active relapsing-remitting MS. This is a prospective observational case series. Fourteen pregnancies of 13 women resulted in 13 live births (one twin pregnancy), nine exposed to GA throughout pregnancy. There were no birth defects and treatment was well tolerated. No relapses occurred during pregnancy in those continuing on treatment. In conclusion, our early experience suggests that when considering the risks and benefits of treatment withdrawal prior to pregnancy, it may be reasonable to continue GA in those patients with previously highly active disease. Consideration should also be given to the initiation of a birth register, similar to such initiatives in epilepsy, to generate more robust safety data in this controversial area.
Authors:
Heidi J Salminen; Helen Leggett; Mike Boggild
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Publication Detail:
Type:  Journal Article     Date:  2010-07-13
Journal Detail:
Title:  Journal of neurology     Volume:  257     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2020-3     Citation Subset:  IM    
Affiliation:
Neonatal Unit, Women and Children's Division, Wirral University Teaching Hospital NHS Trust, Arrowe Park Road, Upton, Wirral, CH49 5PE, UK. hjsalminen@doctors.org.uk
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