Document Detail


Glassy cell carcinoma of the uterine cervix: histochemical, immunohistochemical, and molecular genetic observations.
MedLine Citation:
PMID:  11917222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glassy cell carcinoma (GCC) of the uterine cervix is characterized by distinctive cytological features and an aggressive clinical course. Although this tumor has been usually considered a poorly differentiated variety of adenosquamous carcinoma (ASC), a clarification of the phenotype and histogenesis of GCC is still required. We examined three GCCs and four ASCs for histochemical and immunohistochemical phenotypes and molecular genetic status, comparing them with five nonkeratinizing squamous cell carcinomas and five endocervical-type mucinous adenocarcinomas. GCCs had a profile of cytokeratin expression similar to that of reserve cells or immature squamous cells of the cervix. In addition to squamous differentiation, GCCs sporadically produced intestinal-type mucin. HPV 18 was detected in two of three GCCs and two of four ASCs. GCCs may originate from multipotential stem or reserve cells that undergo early squamous differentiation. The presence of HPV 18 might stimulate biphasic squamous and glandular differentiation.
Authors:
Noriko Kato; Yousei Katayama; Mitsuomi Kaimori; Teiichi Motoyama
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  21     ISSN:  0277-1691     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-27     Completed Date:  2004-09-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-40     Citation Subset:  IM    
Affiliation:
Department of Pathology, Yamagata University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma, Mucinous / genetics*,  pathology*
Carcinoma, Adenosquamous / genetics*,  pathology*
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Keratins / biosynthesis
Microsatellite Repeats
Molecular Biology
Mucin-1 / biosynthesis
Mucin-2
Mucins / biosynthesis
Oncogene Proteins, Viral / metabolism
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Uterine Cervical Neoplasms / genetics*,  pathology*
Chemical
Reg. No./Substance:
0/MUC2 protein, human; 0/Mucin-1; 0/Mucin-2; 0/Mucins; 0/Oncogene Proteins, Viral; 68238-35-7/Keratins

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