Document Detail

Glass ampoules: risks and benefits.
MedLine Citation:
PMID:  21724014     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Glass ampoules have been widely used in packaging injection drugs. Glass has important characteristics that allow it to be widely used in fabrication of recipients for drugs and other sterile substances. However, contamination of solutions with glass microparticles on breaking open glass ampoules, the presence of metals, percutaneous injury, and biological contamination justify the need of educational materials to orient the manipulation of ampoules.
CONTENTS: Glass microparticles generated in the snap-opening of ampoules, as well as metals that contaminate their contents can be aspirated and injected through several routes. Exogenous contaminations by glass and metals can reach several sites in the organism. They trigger organic reactions that may give rise to injuries. Opening ampoules can expose professionals to the risk of percutaneous injuries. These lesions increase the biological risk as they are the gateway for viruses and bacteria. Ampoules opening systems (VIBRAC and OPC) have been developed to reduce the incidence of such accidents. Alternative materials to glass may represent an interesting strategy to increase safety. The use of prefilled syringes may represent an evolution regarding safety.
CONCLUSIONS: Team training and information provided by the pharmaceutical industry on the use of ampoules are fundamental in the prophylaxis of accidents and contaminations. The search for safer materials to replace glass is also important.
Antônio Roberto Carraretto; Erick Freitas Curi; Carlos Eduardo David de Almeida; Roberta Eleni Monteiro Abatti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista brasileira de anestesiologia     Volume:  61     ISSN:  1806-907X     ISO Abbreviation:  Rev Bras Anestesiol     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-12-19     Revised Date:  2014-02-05    
Medline Journal Info:
Nlm Unique ID:  0401316     Medline TA:  Rev Bras Anestesiol     Country:  Brazil    
Other Details:
Languages:  eng; mul     Pagination:  513-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Editora Ltda. All rights reserved.
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MeSH Terms
Drug Contamination / prevention & control
Drug Packaging* / standards
Health Personnel
Occupational Injuries / prevention & control
Risk Factors
Risk Management

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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