Document Detail

Gla-containing proteins of bone.
MedLine Citation:
PMID:  2691199     Owner:  NLM     Status:  MEDLINE    
Bone has high levels of two proteins which contain the vitamin K-dependent Ca2+ binding amino acid, gamma-carboxyglutamic acid (Gla). Bone Gla protein (BGP, osteocalcin) is a 49 residue water soluble protein and matrix Gla protein (MGP) is a 79 residue water insoluble protein. BGP is synthesized only by calcified tissues while MGP is synthesized by calcified tissues, cartilage, and all soft tissues tested. The synthesis of both proteins in osteoblastic cells is stimulated by 1,25(OH)2D3. Treatment of rats with the vitamin K antagonist Warfarin causes secretion of a non-gamma-carboxylated BGP which cannot bind to hydroxyapatite. Warfarin treatment reduces bone levels of BGP to 2% of normal, but does not appear to affect the structure of bone. The only abnormality seen in rats treated with Warfarin is the mineralization of several cartilages. The pattern of cartilage calcification is similar to that seen in the fetal Warfarin syndrome in humans, and may be due to abnormal synthesis of MGP.
P A Price
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Connective tissue research     Volume:  21     ISSN:  0300-8207     ISO Abbreviation:  Connect. Tissue Res.     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-14     Completed Date:  1990-02-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0365263     Medline TA:  Connect Tissue Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  51-7; discussion 57-60     Citation Subset:  IM; S    
Department of Biology, University of California, San Diego, La Jolla 92093.
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MeSH Terms
Amino Acid Sequence
Bone and Bones / analysis*
Calcium-Binding Proteins* / biosynthesis,  physiology
Extracellular Matrix Proteins*
Molecular Sequence Data
Organ Specificity
Osteocalcin* / biosynthesis,  physiology
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Extracellular Matrix Proteins; 0/matrix Gla protein; 104982-03-8/Osteocalcin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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