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Ginsenoside-Rb1 and tetramethylpyrazine phosphate act synergistically to prevent dilated cardiomyopathy in cTnTR141W transgenic mice.
MedLine Citation:
PMID:  22240916     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT: Ginsenoside-Rb1 (Rb1) is known to be partially associated with the inhibition of heparin-binding epidermal growth factor-like growth factor (HB-EGF). Tetramethylpyrazine phosphate (TMPP) inhibits the activation of calcium/calmodulin/calmodulin-dependent protein kinase (Ca/CaM/CaMKII) pathway. The α-myosin heavy chain (α-MHC)-cTnT transgenic mouse was previously reported as a model for dilated cardiomyopathy (DCM), and it was used to test the effects of combinations of Rb1 and TMPP in reversing the progression of DCM and the potential mechanism. Survival, echocardiography, histologic features assessed the effectiveness of Rb1 and TMPP treatments. Western blot and reverse transcription polymerase chain reactions (RT-PCR) were used to determine expression levels of certain genes. The present study clearly demonstrated that treatment with a combination of Rb1 and TMPP could inhibit the expression of HB-EGF, calmodulin1 (Calm1) and calcium/calmodulin-dependent protein kinase II beta (Camk2b). Rb1 alone mainly reduced the expression of HB-EGF, and TMPP alone mainly reduced the expression of Calm1 and Camk2b. Treatment with Rb1 and TMPP had synergistic effects on amelioration of chamber dilation, contractile dysfunction, interstitial fibrosis and ultrastructural degeneration in cTnT mice when compared with results of treatment with Rb1 or TMPP alone, and those were probably due to the inhibition of both HB-EGF and the Ca/CaM/CaMKII pathway.
Authors:
Lu Dan; Shao Hai-Tao; Ge Wen-Ping; Liu Ning; Zhang Xu; Ma Chun-Mei; Qin Chuan; Zhang Lian-Feng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-11
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Key Laboratory of Human Disease Comparative Medicine, Ministry of Health †Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, China.
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