Document Detail

Ginsenoside F1 attenuates hyperpigmentation in B16F10 melanoma cells by inducing dendrite retraction and activating Rho signaling.
MedLine Citation:
PMID:  25381719     Owner:  NLM     Status:  Publisher    
Ginsenoside F1 (GF1) is a metabolite produced by hydrolysis of the ginsenoside Re and Rg1 in Panax ginseng. According to various studies, high amounts of ginseng components are absorbed in the metabolized form, which are key constituents responsible for the biological effects of P. ginseng. Recently, GF1 was reported to have beneficial effects on skin. However, there has not been fully understood its anti-melanogenic effect and underlying molecular mechanisms. In the present study, GF1 reduced α-MSH-induced melanin secretion in B16F10 cell culture media by 60%. However, it did not suppress intracellular melanin levels, tyrosinase activity and expression. Immunofluorescence assay showed that GF1 had no effect on melanosome transport, but significantly induced dendrite retraction. Pull-down assay demonstrated that GF1 primarily modulate the Rho family GTPases resulting in dendrite retraction. Collectively, these data suggest that GF1 could act as a potent skin whitening agent. This article is protected by copyright. All rights reserved.
Ji Hye Kim; Eun Ji Baek; Eun Ju Lee; Myung Hun Yeom; Jun Seong Park; Ki Won Lee; Nam Joo Kang
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Publication Detail:
Type:  LETTER     Date:  2014-11-8
Journal Detail:
Title:  Experimental dermatology     Volume:  -     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-10     Completed Date:  -     Revised Date:  2014-11-11    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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