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Ginkgo biloba extract did not reduce risk for Alzheimer disease in elderly patients with memory complaints.
MedLine Citation:
PMID:  23318341     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
QUESTION In elderly patients who report memory complaints to their primary care physicians, does ginkgo biloba extract reduce risk for Alzheimer disease (AD)? METHODS DESIGN Randomized placebo-controlled trial (GuidAge). ClinicalTrials.gov NCT00276510. ALLOCATION Concealed.* BLINDING Blinded* (patients, clinicians, and dementia adjudication committee). FOLLOW-UP PERIOD Median 5 years. Follow-up after 2 years was < 80%. SETTING 712 primary care physicians at clinical research networks, and 25 memory centers in France. PATIENTS 2854 community-living adults ≥ 70 years of age (mean age 76 y, 67% women) who consulted their primary care physicians or a memory center for memory problems, had an identified proxy, and scored > 25 on the Mini-Mental State Examination, < 6 on the Covi Anxiety Scale, and < 15 on a geriatric depression scale. Exclusion criteria included major objective memory impairment; diagnosis of dementia, major depression, or generalized anxiety; or Clinical Dementia Rating > 0.5. INTERVENTION Standardized ginkgo biloba extract, 120 mg twice per day (n = 1419), or placebo (n = 1435). OUTCOMES Probable AD (Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Diseases and Related Disorders Association criteria). Secondary outcomes included adverse events. PATIENT FOLLOW-UP 85% at 2 years. MAIN RESULTS Groups did not differ for AD at years 1 or 2 (Table); for cumulative incidence of AD over 5 years (4.3% vs 5.2%, P = 0.31); or for such adverse events as death, stroke, hemorrhagic events, or cardiac disorders (all P≥ 0.55). CONCLUSION Ginkgo biloba extract did not reduce risk for Alzheimer disease in elderly patients who reported memory complaints to their primary care physicians.Ginkgo biloba extract vs placebo for incident Alzheimer disease in elderly patients with memory complaints†YearGinkgo biloba extractPlaceboRRR (95% CI)NNT10.7%1.0%28% (-61 to 68)Not significantRRI (CI)NNH21.7%1.0%65% (-19 to 236)Not significant†Abbreviations defined in Glossary. RRR, RRI, NNT, NNH, and CI calculated from placebo event rates and hazard ratios in article.
Authors:
Calvin Hirsch
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of internal medicine     Volume:  158     ISSN:  1539-3704     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  JC7     Citation Subset:  AIM; IM    
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