| Gingival overgrowth in pediatric heart and heart-lung transplant recipients. | |
| | |
MedLine Citation:
|
PMID: 9436135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Gingival overgrowth is a recognized side effect of cyclosporine therapy with cosmetic and functional sequelae. This study examines the incidence and severity of gingival overgrowth in pediatric heart and heart-lung transplant recipients. METHODS: Thirty-one pediatric heart and heart-lung transplant recipients underwent a comprehensive dental evaluation. The severity of gingival overgrowth was scored by use of dental plaster casts. Parameters of dental hygiene in each patient included both a plaque index and a gingival inflammation index. The mean cyclosporine level and daily dose (mg/kg/day) at 3 and 12 months after transplantation and at latest follow-up were determined. RESULTS: The mean (+/- SD) patient age at transplantation was 10.5 (+/- 5.5) years, and the mean duration of posttransplantation follow-up was 3.2 (+/- 2.1) years. In all 30/31 (97%) of the cohort had some degree of overgrowth, with children aged less than 10 years at time of transplantation the most severely affected. By univariate analysis gingival overgrowth was inversely related to age at time of transplantation (r = -0.67, p < 0.001). With multiple regression analysis, only age at transplantation was significantly related to gingival overgrowth. CONCLUSIONS: Gingival overgrowth occurs in most pediatric heart and heart-lung transplant recipients treated with cyclosporine and is most severe in the younger patients. Attention to oral hygiene may improve gingival health parameters; however, the daily weight-adjusted dose of cyclosporine is not related to the severity of overgrowth. |
| | |
Authors:
|
N M Kilpatrick; R G Weintraub; J O Lucas; A Shipp; T Byrt; J L Wilkinson |
Related Documents
:
|
12057705 - Video-assisted thoracoscopic surgery for primary chylopericardium after orthotopic hear... 9257255 - The alternate recipient list for heart transplantation: does it work? 12089735 - Smooth muscle cells transplantation is better than heart cells transplantation for impr... 3048215 - Orthotopic transplantation during early infancy as therapy for incurable congenital hea... 916135 - Spontaneous renal disease in louisiana armadillos (dasypus novemcinctus). 10694605 - Heart-lung versus double-lung transplantation for suppurative lung disease. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 16 ISSN: 1053-2498 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 1997 Dec |
Date Detail:
|
Created Date: 1998-02-26 Completed Date: 1998-02-26 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1231-7 Citation Subset: IM |
Affiliation:
|
Department of Dentistry, Royal Children's Hospital, Melbourne, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Analysis of Variance Body Weight Child Child, Preschool Cohort Studies Cyclosporine / administration & dosage, adverse effects*, blood Dental Models Dental Plaque Index Esthetics, Dental Female Follow-Up Studies Gingival Overgrowth / chemically induced*, classification Gingivitis / chemically induced Heart Transplantation* Heart-Lung Transplantation* Humans Immunosuppressive Agents / administration & dosage, adverse effects*, blood Incidence Male Oral Hygiene Periodontal Index Regression Analysis |
| Chemical | |
Reg. No./Substance:
|
0/Immunosuppressive Agents; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Medium-term results of pediatric patients undergoing orthotopic heart transplantation.
Next Document: Perioperative management of pulmonary hypertension after heart transplantation in childhood.