Document Detail

Gingival inflammatory infiltrate analysis in patients with chronic periodontitis and diabetes mellitus.
MedLine Citation:
PMID:  22203939     Owner:  NLM     Status:  MEDLINE    
MATERIALS AND METHODS: The study was achieved on gingival tissue from 40 patients with DM and specific symptoms of periodontal disease. We used Hematoxylin-Eosin and trichromic Goldner-Szekely staining and CD20cy and CD45RO antibodies.
RESULTS: In patients with DM under 10 years, we found an intense periodontal lymphocyte inflammatory infiltrate and in patients with a DM evolution more than 10 years, the lymphocyte inflammatory infiltrate had a less intensity. The pattern was mostly diffuse in lamina propria. Many patients had a very abundant plasmocyte infiltrate. During immunohistochemical exam, 25 cases presented CD20 positive immunostaining. The intensity of the inflammatory infiltrate with B-lymphocytes was very low (score 1). All immunohistochemical analyzed cases presented CD45RO positive immunostaining, with a mixed pattern of the T-cell lymphocyte infiltrate.
CONCLUSIONS: The nflammatory infiltrate in diabetic periodontal disease was polymorph, mostly with a diffuse pattern in gingival chorion. The intensity of the lymphocyte infiltrate was higher in patients with chronic periodontitis and DM less than 10 years. Positive CD45RO T-lymphocytes were more numerous compared to positive CD20 B-lymphocytes and they were present intra and under epithelial in the gingival of all the patients, no matter of the DM time evolution.
Mădălina Olteanu; Petra Surlin; B Oprea; Anne Marie Rauten; R M Popescu; Mimi Niţu; Georgiana Cristiana Camen; O Caraivan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie     Volume:  52     ISSN:  1220-0522     ISO Abbreviation:  Rom J Morphol Embryol     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-28     Completed Date:  2012-04-23     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9112454     Medline TA:  Rom J Morphol Embryol     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  1311-7     Citation Subset:  IM    
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MeSH Terms
Antigens, CD20 / metabolism
Antigens, CD45 / metabolism
Chronic Periodontitis / complications*,  pathology*
Diabetes Mellitus / pathology*
Gingiva / pathology*
Inflammation / complications*,  pathology*
Lymphocytes / pathology
Reg. No./Substance:
0/Antigens, CD20; EC, CD45

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