Document Detail

Gingival crevicular fluid levels of oncostatin M in periodontal conditions.
MedLine Citation:
PMID:  20189410     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid of gingivitis and chronic periodontitis patients and effect of periodontal therapy on OSM concentration in GCF of chronic periodontitis patients. DESIGN: A total of 60 subjects were divided into three groups (n=20) based on gingival index (GI), probing pocket depth (PPD) and clinical attachment loss (CAL): healthy (group I), gingivitis (group II) and chronic periodontitis (group III). A fourth group (group IV) consisted of 20 subjects from group III, 8 weeks after treatment i.e. scaling and root planning (SRP). GCF samples were collected from all the groups to estimate the levels of OSM using Enzyme-Linked ImmunoSorbentAssay (ELISA). RESULT: The mean OSM concentrations in GCF was found to be the highest in group III i.e. 0.81+/-0.33 pg/microl. The mean OSM concentration in group I was 0.0689+/-0.022 pg/microl in GCF and in group IV it was 0.0943+/-0.037 g/microl). For group II the mean OSM concentration in GCF 0.125+/-0.023 pg/microl, was fell in between the concentrations obtained in groups I and III. CONCLUSIONS: The greater the amount of periodontal tissue destruction there is substantial increase in GCF OSM concentrations. Since, OSM levels are positively correlated with PPD and CAL, it can be considered as an inflammatory biomarker in periodontal diseases.
S Thorat Manojkumar; A R Pradeep; Garima Garg; Arjun Raju
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-26
Journal Detail:
Title:  Cytokine     Volume:  50     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-07-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  248-52     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Department of Periodontics, Government Dental College and Research Institute, Bangalore 560002, Karnataka, India.
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MeSH Terms
Gingival Crevicular Fluid / metabolism*
Oncostatin M / metabolism*
Periodontal Diseases / metabolism*
Periodontal Index
Reg. No./Substance:
106956-32-5/Oncostatin M

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