| Ginger suppresses phthalate esters-induced airway remodeling. | |
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MedLine Citation:
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PMID: 21370925 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study has two novel findings: it is not only the first to demonstrate inflammatory cytokines, which are produced by the bronchial epithelium after exposure to phthalate esters and contribute to airway remodeling by increasing human bronchial smooth muscle cells (BSMC) migration and proliferation, but it is also the first to reveal that ginger reverses phthalate esters-mediated airway remodeling. We treated human bronchial epithelial cell lines BEAS-2B and HBE135-E6E7 (HBE) with butylbenzyl phthalate (BBP), bis-(2-ethylhexyl) phthalate (BEHP), dibutyl phthalate (DBP), and diethyl phthalate (DEP), then harvested the conditioned medium (CM), which was then added to BSMC. Cultures of BSMC with BBP-, BEHP-, DBP-, and DEP-BEAS-2B-CM and DEP-HBE-CM increased BSMC proliferation and migration, which are major features in asthma remodeling. Exposure of BEAS-2B and HBE to DBP caused epithelial cells to produce inflammatory cytokines IL-8 and RANTES, which subsequently induced BSMC proliferation and migration. Depleting both IL-8 and RANTES completely reversed the effect of DBP-BEAS-2B-CM and DBP-HBE-CM-mediated BSMC proliferation and migration, suggesting this effect is a synergistic influence of IL-8 and RANTES. Moreover, [6]-shogaol, [6]-gingerol, [8]-gingerol and [10]-gingerol, which are major bioactive compounds present in Zingiber officinale, suppress phthalate esters-mediated airway remodeling. Our study suggests that ginger is capable of preventing phthalate esters-associated asthma. |
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Authors:
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Po-Lin Kuo; Ya-Ling Hsu; Ming-Shyan Huang; Ming-Ju Tsai; Ying-Chin Ko |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-3 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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