Document Detail

Ginger extract reduces delayed gastric emptying and nosocomial pneumonia in adult respiratory distress syndrome patients hospitalized in an intensive care unit.
MedLine Citation:
PMID:  20149584     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study was to evaluate the effect of ginger extract on delayed gastric emptying, developing ventilator-associated pneumonia, and clinical outcomes in adult respiratory distress syndrome (ARDS).
MATERIALS AND METHODS: Thirty-two ARDS patients who were dependent on mechanical ventilation and fed via nasogastric tube were studied. After enrollment, patients were randomized to 2 groups. The control group received 1 g of coconut oil as placebo, and the study group received 120 mg of ginger extract. The amount of feeding tolerated at the first 48 hours of feeding, amount of feeding tolerated during the entire study period, nosocomial pneumonia, number of intensive care unit (ICU)-free days, number of ventilator-free days, and mortality were evaluated during 21 days of intervention.
RESULTS: There was a significant difference between the ginger group and the control group in the amount of feeding tolerated at the first 48 hours of enteral feeding (51% vs 57%, P < .005). There was a trend toward a decrease in pneumonia in the ginger group (P = .07). The overall in-ICU mortality was 15.6%, with no significant difference in the 2 groups. The number of ventilator-free days and that of ICU-free days were lower in the control group compared with the ginger group (P = .04 and P = .02).
CONCLUSION: This study showed that gastric feed supplementation with ginger extract might reduce delayed gastric emptying and help reduce the incidence of ventilator-associated pneumonia in ARDS.
Zahra Vahdat Shariatpanahi; Fourogh Azam Taleban; Majid Mokhtari; Shaahin Shahbazi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-02-10
Journal Detail:
Title:  Journal of critical care     Volume:  25     ISSN:  1557-8615     ISO Abbreviation:  J Crit Care     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  647-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier Inc.
National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of MS, Tehran, 1981619573, Iran.
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MeSH Terms
Critical Care
Cross Infection / prevention & control*
Double-Blind Method
Gastric Emptying / drug effects
Intensive Care Units
Middle Aged
Plant Extracts / therapeutic use*
Plant Oils / administration & dosage
Pneumonia, Ventilator-Associated / prevention & control*
Respiratory Distress Syndrome, Adult / drug therapy*
Treatment Outcome
Reg. No./Substance:
0/Plant Extracts; 0/Plant Oils; 8001-31-8/coconut oil

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