Document Detail


Gilles de la Tourette's syndrome in twins: clinical and neurochemical data.
MedLine Citation:
PMID:  1691443     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A pair of identical twins (probability of monozygosity by genetic marking = 99.99%) with Gilles de la Tourette's syndrome (GTS) were studied clinically and neurochemically. The two boys were distinguished within the family by dramatic differences in their behavior and tics. Twin 1 had severe motor tics, loud vocalizations, coprolalia, and school behavior problems, whereas twin 2 was only mildly affected. Neither boy had ever been treated with medication for his tic disorder. Lumbar puncture was performed on each after a night of bed rest. In spite of the marked clinical differences between the two boys, the major indices of dopamine and serotonin turnover in the cerebrospinal fluid were equivalent. Homovanillic acid levels were 65 and 60 ng/ml, respectively, and 5-hydroxyindoleacetic acid levels were 36 and 39 ng/ml. Observation of these twins suggests that the phenotypic expression of GTS relates to more factors than inheritance. Neurochemical metabolites of dopamine and serotonin did not reflect the comparative clinical severity of GTS in these boys.
Authors:
C G Goetz; C M Tanner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  5     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1990  
Date Detail:
Created Date:  1990-05-24     Completed Date:  1990-05-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-5     Citation Subset:  IM    
Affiliation:
Department of Neurological Sciences, Rush Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
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MeSH Terms
Descriptor/Qualifier:
Child
Diseases in Twins / genetics*
Homovanillic Acid / cerebrospinal fluid
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid
Male
Tourette Syndrome / cerebrospinal fluid,  genetics*,  physiopathology
Chemical
Reg. No./Substance:
306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid
Comments/Corrections
Comment In:
Mov Disord. 1991;6(4):384   [PMID:  1758465 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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