| Gilbert's syndrome and hyperbilirubinaemia in ABO-incompatible neonates. | |
| | |
MedLine Citation:
|
PMID: 10968441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We asked whether UDP glucuronosyltransferase (UGT) gene promoter polymorphism (Gilbert's syndrome) would increase hyperbilirubinaemia in direct Coombs' negative ABO-incompatible neonates, as seen in other combinations with this condition. 40 ABO-incompatible and 344 ABO-compatible controls had an allele frequency of 0.35 for the variant promoter gene. The incidence of hyperbilirubinaemia was significantly higher only in the former who were also homozygotes for the variant UGT promoter, compared with ABO-incompatible babies homozygous for the normal UGT promoter (43% vs 0, p=0.02), and with ABO-compatible controls of all UGT genotypes combined (relative risk 5.65, 95% CI 2.23-14.31). Gilbert's syndrome is a determining factor for neonatal hyperbilirubinaemia ABO incompatibility. |
| | |
Authors:
|
M Kaplan; C Hammerman; P Renbaum; G Klein; E Levy-Lahad |
Publication Detail:
|
Type: Letter |
Journal Detail:
|
Title: Lancet Volume: 356 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 2000 Aug |
Date Detail:
|
Created Date: 2000-09-20 Completed Date: 2000-09-20 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 652-3 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
ABO Blood-Group System
/
genetics Alleles Blood Group Incompatibility / epidemiology* Cohort Studies Comorbidity Coombs' Test DNA Mutational Analysis Gene Frequency Gilbert Disease / epidemiology*, genetics* Glucuronosyltransferase / genetics Heterozygote Homozygote Humans Incidence Infant, Newborn Jaundice, Neonatal / epidemiology* Polymerase Chain Reaction Promoter Regions, Genetic / genetics Risk |
| Chemical | |
Reg. No./Substance:
|
0/ABO Blood-Group System; EC 2.4.1.17/Glucuronosyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failure...
Next Document: Retroperitoneal endoscopic debridement for infected peripancreatic necrosis.