| Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg? | |
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MedLine Citation:
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PMID: 20070246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gilbert's syndrome is characterized by mild unconjugated nonhemolytic hyperbilirubinemia, without hepatic inflammation, fibrosis, chronic liver disease, or liver failure. It is readily diagnosed by genetic variants of the UGT1A1 gene, mainly UGT1A1*28, and is also associated with abnormalities of hepatobiliary transport and additional UGT1A gene variants. Apart from representing a potential risk factor in irinotecan and protease inhibitor therapy, it appears to exert protective effects in Hodgkin's lymphoma and cardiovascular disease. Gilbert's syndrome is part of a continuous spectrum of altered glucuronidation that extends to fatal Crigler-najjar disease. The complexity hidden behind this pharmacogenetic abnormality is of profound significance for drug development and therapy. |
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Authors:
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Christian P Strassburg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Drug metabolism reviews Volume: 42 ISSN: 1097-9883 ISO Abbreviation: Drug Metab. Rev. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-14 Completed Date: 2010-05-03 Revised Date: 2011-01-19 |
Medline Journal Info:
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Nlm Unique ID: 0322067 Medline TA: Drug Metab Rev Country: England |
Other Details:
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Languages: eng Pagination: 168-81 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany. strassburg.christian@mh-hannover.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Crigler-Najjar Syndrome
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genetics* Gene Frequency Genetic Predisposition to Disease Gilbert Disease / genetics* Glucuronosyltransferase / genetics*, metabolism Hyperbilirubinemia / epidemiology Jaundice / complications, genetics* Pharmacogenetics* Polymorphism, Single Nucleotide Risk Factors |
| Chemical | |
Reg. No./Substance:
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EC 2.4.1.-/bilirubin uridine-diphosphoglucuronosyl transferase 1A1; EC 2.4.1.17/Glucuronosyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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