Document Detail


Gibberellin signaling controls cell proliferation rate in Arabidopsis.
MedLine Citation:
PMID:  19576768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plant growth involves the integration of many environmental and endogenous signals that together with the intrinsic genetic program determine plant size. At the cellular level, growth rate is regulated by the combined activity of two processes: cell proliferation and expansion. Gibberellins (GA) are plant-specific hormones that play a central role in the regulation of growth and development with respect to environmental variability. It is well established that GA promote growth through cell expansion by stimulating the destruction of growth-repressing DELLA proteins (DELLAs); however, their effects on cell proliferation remain unknown. Kinematic analysis of leaf and root meristem growth revealed a novel function of DELLAs in restraining cell production. Moreover, by visualizing the cell cycle marker cyclinB1::beta-glucuronidase in GA-signaling mutants, we show that GA modulate cell cycle activity in the root meristem via a DELLA-dependent mechanism. Accordingly, expressing gai (a nondegradable DELLA protein) solely in root meristem reduced substantially the number of dividing cells. We also show that DELLAs restrain cell production by enhancing the levels of the cell cycle inhibitors Kip-related protein 2 (KRP2) and SIAMESE (SIM). Therefore, DELLAs exert a general plant growth inhibitory activity by reducing both cell proliferation and expansion rates, enabling phenotypic plasticity.
Authors:
Patrick Achard; Andi Gusti; Soizic Cheminant; Malek Alioua; Stijn Dhondt; Frederik Coppens; Gerrit T S Beemster; Pascal Genschik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-02
Journal Detail:
Title:  Current biology : CB     Volume:  19     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-30     Completed Date:  2009-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1188-93     Citation Subset:  IM    
Affiliation:
Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Conventionné avec l'Université de Strasbourg, 67084 Strasbourg, France.
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / growth & development*
Arabidopsis Proteins / metabolism*
Cell Cycle Proteins / metabolism
Cell Proliferation
Gibberellins / metabolism*
Meristem / growth & development,  metabolism
Plant Growth Regulators / metabolism*
Plant Leaves / growth & development,  metabolism
Signal Transduction / physiology*
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Cell Cycle Proteins; 0/GAI protein, Arabidopsis; 0/Gibberellins; 0/ICK2 protein, Arabidopsis; 0/Plant Growth Regulators; 0/SIAMESE protein, Arabidopsis

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