| Giardiasis treatment in Turkish children with a single dose of ornidazole. | |
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MedLine Citation:
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PMID: 12587625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to compare the treatment efficacy of single dose of ornidazole with 5 d treatments of ornidazole and metronidazole in children with giardiasis. 175 children, between 2 and 15 y old, whose stool samples were found to be positive for Giardia lamblia cysts and/or trophozoites by either saline-Lugol, formalin-ethyl acetate or trichrome staining, were enrolled in the study. Of these children, 105 were treated with a single dose of ornidazole: 35 with 30 mg/kg, 35 with 25 mg/kg and 35 with 20 mg/kg; 35 were treated with 25 mg/kg per day of ornidazole for 5 d in 2 doses and 35 children were treated with 20 mg/kg per day metronidazole for 7 d in 3 doses. All cases were examined on the 7th, 10th and 14th days after treatment by the same methods; clinical symptoms were also evaluated. Giardia lamblia was eradicated in 34 of 35 (97%), 34 of 35 (97%) and 33 of 35 (94%) patients treated with 30, 25 and 20 mg/kg single doses of ornidazole, respectively. Eradication was achieved in all 35 patients treated with 25 mg/kg per day ornidazole for 5 d and in 31 of 35 (89%) patients treated with metronidazole. There was no statistically significant difference among doses of ornidazole (p > 0.05); however, all ornidazole treatment regimens were significantly more effective than metronidazole treatment (p < 0.05). No important side-effects were detected in any patients and clinical symptoms disappeared in all. Single-dose ornidazole treatment could be considered as a proper and effective alternative method for the treatment of giardiasis in children. |
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Authors:
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Ahmet Ozbilgin; Pelin Ertan; Kor Yereli; A Taylan Tamay; Ozgür Kurt; Kenan Degerli; I Cüneyt Balcioglu; Ulgen Z Ok; Ali Onag |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Scandinavian journal of infectious diseases Volume: 34 ISSN: 0036-5548 ISO Abbreviation: Scand. J. Infect. Dis. Publication Date: 2002 |
Date Detail:
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Created Date: 2003-02-17 Completed Date: 2003-03-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0215333 Medline TA: Scand J Infect Dis Country: Sweden |
Other Details:
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Languages: eng Pagination: 918-20 Citation Subset: IM |
Affiliation:
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Department of Parasitology, Celal Bayar University School of Medicine, Manisa, Turkey. ozbilgin@dr.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antiprotozoal Agents / administration & dosage, therapeutic use* Child, Preschool Giardiasis / drug therapy*, epidemiology Humans Metronidazole / therapeutic use Ornidazole / administration & dosage, therapeutic use* Treatment Outcome Turkey / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Antiprotozoal Agents; 16773-42-5/Ornidazole; 443-48-1/Metronidazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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