Document Detail


Giardiasis treatment in Turkish children with a single dose of ornidazole.
MedLine Citation:
PMID:  12587625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to compare the treatment efficacy of single dose of ornidazole with 5 d treatments of ornidazole and metronidazole in children with giardiasis. 175 children, between 2 and 15 y old, whose stool samples were found to be positive for Giardia lamblia cysts and/or trophozoites by either saline-Lugol, formalin-ethyl acetate or trichrome staining, were enrolled in the study. Of these children, 105 were treated with a single dose of ornidazole: 35 with 30 mg/kg, 35 with 25 mg/kg and 35 with 20 mg/kg; 35 were treated with 25 mg/kg per day of ornidazole for 5 d in 2 doses and 35 children were treated with 20 mg/kg per day metronidazole for 7 d in 3 doses. All cases were examined on the 7th, 10th and 14th days after treatment by the same methods; clinical symptoms were also evaluated. Giardia lamblia was eradicated in 34 of 35 (97%), 34 of 35 (97%) and 33 of 35 (94%) patients treated with 30, 25 and 20 mg/kg single doses of ornidazole, respectively. Eradication was achieved in all 35 patients treated with 25 mg/kg per day ornidazole for 5 d and in 31 of 35 (89%) patients treated with metronidazole. There was no statistically significant difference among doses of ornidazole (p > 0.05); however, all ornidazole treatment regimens were significantly more effective than metronidazole treatment (p < 0.05). No important side-effects were detected in any patients and clinical symptoms disappeared in all. Single-dose ornidazole treatment could be considered as a proper and effective alternative method for the treatment of giardiasis in children.
Authors:
Ahmet Ozbilgin; Pelin Ertan; Kor Yereli; A Taylan Tamay; Ozgür Kurt; Kenan Degerli; I Cüneyt Balcioglu; Ulgen Z Ok; Ali Onag
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  34     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2002  
Date Detail:
Created Date:  2003-02-17     Completed Date:  2003-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  918-20     Citation Subset:  IM    
Affiliation:
Department of Parasitology, Celal Bayar University School of Medicine, Manisa, Turkey. ozbilgin@dr.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antiprotozoal Agents / administration & dosage,  therapeutic use*
Child, Preschool
Giardiasis / drug therapy*,  epidemiology
Humans
Metronidazole / therapeutic use
Ornidazole / administration & dosage,  therapeutic use*
Treatment Outcome
Turkey / epidemiology
Chemical
Reg. No./Substance:
0/Antiprotozoal Agents; 16773-42-5/Ornidazole; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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