Document Detail

Giant placental chorioangioma: natural history and pregnancy outcome.
MedLine Citation:
PMID:  19859897     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Giant placental chorioangiomas are associated with a high prevalence of pregnancy complications and a poor perinatal outcome. The aim of the study was to evaluate the natural history, intrauterine treatment and outcome of pregnancies complicated by giant placental chorioangioma. METHODS: This was a retrospective study of 19 cases of giant placental chorioangioma, in which the natural history, intrauterine treatment and outcome of pregnancy were evaluated. RESULTS: Eighteen of the 19 cases were associated with a wide variety of fetal complications, including polyhydramnios, growth restriction, hyperdynamic circulation, cardiomegaly, anemia and non-immune hydrops. Two-thirds of the cases developed complications that required either elective delivery for fetal growth restriction (n = 6) or intervention for cardiovascular effects (n = 7). Fetal therapy, when required, was tailored to the particular complication and resulted in a successful pregnancy in all cases. CONCLUSIONS: The presence of large placental chorioangioma is associated with the development of fetal growth restriction and hyperdynamic state in a significant number of cases. This series elucidates some of the putative underlying mechanisms for these complications, and reports on a safe and effective treatment modality, percutaneous ultrasound-guided interstitial laser therapy.
C Zanardini; A Papageorghiou; A Bhide; B Thilaganathan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  35     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  332-6     Citation Subset:  IM    
Copyright Information:
(c) 2009 ISUOG. Published by John Wiley & Sons, Ltd.
Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, St George's Hospital Medical School, London, UK.
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MeSH Terms
Fetal Growth Retardation / etiology,  ultrasonography*
Hemangioma / complications,  surgery,  ultrasonography*
Infant, Newborn
Laser Coagulation
Placenta Diseases / surgery,  ultrasonography*
Polyhydramnios / etiology,  ultrasonography
Pregnancy Complications, Neoplastic / surgery,  ultrasonography*
Pregnancy Outcome
Retrospective Studies
Ultrasonography, Prenatal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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