Document Detail

Giant lamellar bodies in alveolar type II cells of rats exposed to a low concentration of ozone.
MedLine Citation:
PMID:  6548572     Owner:  NLM     Status:  MEDLINE    
The effect of a low concentration of ozone on pulmonary surfactant release was examined by the ultrastructural morphometry of lamellar bodies in alveolar type II cells. Rats were exposed to approximately 0.3 ppm of ozone for 3 h daily for 16 consecutive days. The volume density of lamellar bodies, relative to the cell, increased significantly following ozone exposure. After 11 days giant lamellar bodies were found in ozone-exposed rats. These findings suggest that ozone exposure causes the impairment of pulmonary surfactant release.
S Shimura; S Maeda; T Takismima
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  46     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1984  
Date Detail:
Created Date:  1984-12-19     Completed Date:  1984-12-19     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  303-9     Citation Subset:  IM    
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MeSH Terms
Microscopy, Electron
Ozone / pharmacology*
Pulmonary Alveoli / cytology*,  drug effects,  ultrastructure
Pulmonary Surfactants / metabolism
Rats, Inbred Strains
Vitamin E / pharmacology
Vitamin E Deficiency / pathology
Reg. No./Substance:
0/Pulmonary Surfactants; 10028-15-6/Ozone; 1406-18-4/Vitamin E

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