Document Detail

Giant intrasellar aneurysm presenting with panhypopituitarism and subarachnoid hemorrhage: case report and literature review.
MedLine Citation:
PMID:  8043978     Owner:  NLM     Status:  MEDLINE    
A 52-year-old woman was admitted to our hospital presenting with subarachnoid hemorrhage, left ophthalmoplegia, and right hemiparesis. Previous symptoms and signs suggested the presence of panhypopituitarism. A giant intracranial aneurysm of the internal carotid artery, diagnosed by magnetic resonance imaging, showed the characteristic flow void phenomenon with black appearance. Analysis of endocrine function disclosed panhypopituitarism and hyperprolactinemia. After proximal balloon occlusion of the aneurysm, diabetes insipidus developed. Pituitary function reassessed 6 months after initial admission confirmed anterior and posterior hypopituitarism and hyperprolactinemia. Possible mechanisms are discussed. A review of the literature on pituitary dysfunction caused by carotid artery aneurysms discloses that the pituitary-gonadal axis is the most frequently involved (67.5% of cases), followed by the pituitary-adrenal axis (48.6%) and the pituitary-thyroid axis (40.5%). These frequencies are very similar to those described in other types of hypopituitarism.
J M Fernández-Real; M Fernández-Castañer; C Villabona; E Sagarra; J M Gómez-Sáez; J Soler
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Clinical investigator     Volume:  72     ISSN:  0941-0198     ISO Abbreviation:  Clin Investig     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-09-01     Completed Date:  1994-09-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9207154     Medline TA:  Clin Investig     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  302-6     Citation Subset:  IM    
Department of Endocrinology, Ciutat Sanitària de Bellvitge, Barcelona, Spain.
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MeSH Terms
Carotid Artery, Internal
Diagnosis, Differential
Hypopituitarism / etiology*
Intracranial Aneurysm / complications,  diagnosis*
Middle Aged
Sella Turcica
Subarachnoid Hemorrhage / etiology*

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