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Giant de novo pleomorphic adenoma arising from the parapharyngeal space.
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MedLine Citation:
PMID:  24416608     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Introduction. De novo pleomorphic adenomas in the parapharyngeal space are rare and cause difficulties in its surgical management. We report the largest de novo pleomorphic adenoma arising from the parapharyngeal space and discuss its surgical management. Presentation of Case. A 34-year-old male presented with a giant de novo pleomorphic adenoma arising from the parapharyngeal space, which was initially misdiagnosed as an impacted wisdom tooth. Measuring 8.4 × 6.5 × 3.9 cm in size and weighing 87.3 g, this is the largest primary salivary gland tumour arising de novo from the parapharyngeal space reported in the literature, presenting challenges in its surgical management. Discussion. Parapharyngeal space tumours cause nonspecific symptoms and may be difficult to diagnose, which can allow the tumours to become very large and cause obstructive and compressive symptoms in an anatomically difficult area. A combined trans-cervical and trans-oral approach can be used to safely perform an en bloc resection. Conclusion. We report the diagnosis and surgical management of the largest pleomorphic adenoma arising de novo from the parapharyngeal space reported in the literature.
Authors:
Sang Hwang; Sim Choroomi; Ben McArdle; Ian Jacobson
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Publication Detail:
Type:  Journal Article     Date:  2013-12-12
Journal Detail:
Title:  Case reports in otolaryngology     Volume:  2013     ISSN:  2090-6765     ISO Abbreviation:  Case Rep Otolaryngol     Publication Date:  2013  
Date Detail:
Created Date:  2014-01-13     Completed Date:  2014-01-13     Revised Date:  2014-01-17    
Medline Journal Info:
Nlm Unique ID:  101576603     Medline TA:  Case Rep Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  742910     Citation Subset:  -    
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Journal Information
Journal ID (nlm-ta): Case Rep Otolaryngol
Journal ID (iso-abbrev): Case Rep Otolaryngol
Journal ID (publisher-id): CRIM.OTOLARYNGOLOGY
ISSN: 2090-6765
ISSN: 2090-6773
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright © 2013 Sang Hwang et al.
open-access:
Received Day: 6 Month: 10 Year: 2013
Accepted Day: 21 Month: 11 Year: 2013
Print publication date: Year: 2013
Electronic publication date: Day: 12 Month: 12 Year: 2013
Volume: 2013E-location ID: 742910
PubMed Id: 24416608
ID: 3876594
DOI: 10.1155/2013/742910

Giant De Novo Pleomorphic Adenoma Arising from the Parapharyngeal Space
Sang Hwang12* http://orcid.org/0000-0001-7774-4866
Sim Choroomi1
Ben McArdle1
Ian Jacobson1
1Department of Otolaryngology and Head and Neck Surgery, Prince of Wales Hospital, Randwick, NSW 2031, Australia
2Prince of Wales Hospital Clinical School, University of New South Wales, Kensington, NSW 2052, Australia
Correspondence: *Sang Hwang: syhwang15@gmail.com
[other] Academic Editors: G. Donatini, M. Gupta, W. Issing, and V. A. Resto

1. Introduction

The parapharyngeal space is found anterior to the cervical column, posterior to the infratemporal fossa, and laterally to the nasopharynx. It forms an inverted pyramid with the skull base superiorly and the apex at the joint between the posterior belly of the digastric muscle and the greater cornu of the hyoid bone [1].

Tumours arising de novo in the parapharyngeal space are very rare and present challenges in achieving en bloc excision without spilling the contents of the tumour [1]. We describe the largest primary salivary gland tumour arising de novo from the parapharyngeal space and discuss its management.


2. Case History

A 34-year-old male presented to our multidisciplinary head and neck clinic with a 3-year history of recurrent discomfort in his right retromolar trigone. These episodes were initially diagnosed by a dentist as an impacted wisdom tooth with subclinical infection and were treated with oral antibiotics with minor improvement in symptoms. One year prior to presentation, the patient noticed a prominence on the right side of his oropharynx but this was not reviewed by a medical professional.

Over the last 2 years, the patient had worsening obstructive symptoms, including snoring, episodes of sleep apnoea, nasal speech, and a sensation of decreased hearing in his right ear. The patient also reported 7 kg of weight loss and lethargy in the preceding 3 months before presentation. There was no relevant past medical or family history and the patient took no regular medications. He was a lifelong nonsmoker with occasional consumption of alcohol.

Physical examination revealed a submucosal mass arising from the lateral wall of the right oropharynx, displacing the soft palate and the right anterior tonsillar pillar anteromedially (Figure 1(a)). The mass crossed the midline, narrowing the right oropharyngeal inlet and filling the nasopharynx, causing serous otitis media. Nasoendoscopy defined a mass that extends along the right lateral pharyngeal wall superiorly to the base of skull and inferiorly to the vallecula but not involving the right glossotonsillar sulcus or the posterior 1/3rd of the tongue. There were no lymphadenopathy or cranial nerve deficits.

Magnetic resonance imaging (MRI) demonstrated a well demarcated but lobulated homogenous mass with little contrast enhancement, separate from the deep lobe of the parotid (Figure 1(b)). There were no features to suggest tumour necrosis. A fine needle aspiration biopsy showed features consistent with a salivary gland tumour.

Surgical excision was performed via a combined transoral and transcervical approach, avoiding the need to split his mandible. A linear incision over the patient's right neck and a linear paramedian incision over the soft palate were used and an extracapsular blunt dissection was performed, and the tumour was delivered via the cervical neck en bloc (Figure 2(a)).

One week after-operation, the patient developed a deep space collection of the neck which was surgically drained and treated with intravenous antibiotics with good effect. The patient is well at 3 months from the initial operation.

Pathology revealed a pleomorphic adenoma of the salivary gland, 8.4 × 6.5 × 3.9 cm in size and weighing 87.3 g (Figure 2(b)). A literature search reveals this to be the largest primary salivary gland tumour arising de novo from the parapharyngeal space.


3. Discussion

Parapharyngeal space tumours are rare accounting for only 0.5% of head and neck neoplasms. Up to 80% are benign and 40–50% originate from the salivary glands, with pleomorphic adenoma being the most common [2]. They are often large at the time of presentation as they may be asymptomatic or misdiagnosed when being small [1].

Large parapharyngeal space tumours have been previously reported in literature, but these tumours often originate from the deep lobe of the parotid gland, which extends into the parapharyngeal space through the stylomandibular tunnel [2, 3]. It is rare to diagnose de novo pleomorphic adenoma in the parapharyngeal space [4], and it has been previously suggested that this may be secondary to displaced or aberrant salivary gland tissue [5].

There are numerous external (including transcervical and transparotid) methods to surgically access and perform an extracapsular dissection of parapharyngeal space tumours [1, 4]. In large tumours, this may be combined with a transoral approach, which has been described for excising small, nonvascular neoplasms that originate in the prestyloid compartment of the parapharyngeal space [1].

In this case, a combined trans-cervical and trans-oral approach was used to dissect out the tumour, which was delivered through the cervical incision. This is an effective way of excising giant parapharyngeal space tumours en bloc, maintaining oncological planes and minimizing the risk of spillage of the contents of the tumour.

In summary, we report a giant pleomorphic adenoma arising de novo from the parapharyngeal space. The combined trans-cervical and trans-oral surgical approach was successfully used in this anatomically difficult area and may be considered for excision of such giant tumours in the parapharyngeal space.


References
1. Infante-Cossio P,Gonzalez-Cardero E,Gonzalez-Perez L-M,Leopoldo-Rodado M,Garcia-Perla A,Esteban F. Management of parapharyngeal giant pleomorphic adenomaOral and Maxillofacial SurgeryYear: 20111542112162-s2.0-8155521115421842148
2. Khafif A,Segev Y,Kaplan DM,Gil Z,Fliss DM. Surgical management of parapharyngeal space tumors: a 10-year reviewOtolaryngology—Head and Neck SurgeryYear: 200513234014062-s2.0-1474427005715746851
3. Warrington G,Emery PJ,Gregory MM,Harrison DFN. Pleomorphic salivary gland adenomas of the parapharyngeal space. Review of nine casesJournal of Laryngology and OtologyYear: 19819522052182-s2.0-00193497986257814
4. Hakeem AH,Hazarika B,Pradhan SA,Kannan R. Primary pleomorphic adenoma of minor salivary gland in the parapharyngeal spaceWorld Journal of Surgical OncologyYear: 20097, article 852-s2.0-71049120653
5. Varghese BT,Sebastian P,Abraham EK,Mathews A. Pleomorphic adenoma of minor salivary gland in the parapharyngeal spaceWorld Journal of Surgical OncologyYear: 20031, article22-s2.0-33646214971

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