Document Detail

Giant cell tumor of the larynx: case report and review of the literature.
MedLine Citation:
PMID:  9059875     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Primary manifestation of a giant cell tumor (GCT) in the larynx is exceedingly rare. Until now, only 17 cases have been reported in the literature. Characterization of a GCT can be difficult partly because of similarities with the giant cell subtype of malignant fibrous histiocytoma (MFH). METHODS: The case of a 35-year-old man with a laryngeal GCT is presented. The patient underwent laryngectomy and has been free of recurrence since then (90 months). The literature is reviewed, and previously reported cases are presented in a table and compared with the presented case. The difficulties in the differential diagnosis are discussed. CONCLUSIONS: When a laryngeal GCT is diagnosed, further differential diagnostic considerations should follow. One of these considerations is the MFH, which displays considerably more cellular atypia than GCT. Because most cases of giant cell MFH are high-grade sarcomas, the distinction between GCT and MFH is necessary.
J A Werner; D Harms; A Beigel
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Head & neck     Volume:  19     ISSN:  1043-3074     ISO Abbreviation:  Head Neck     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2006-10-05    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-7     Citation Subset:  IM    
Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Germany.
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MeSH Terms
Biopsy, Needle
Diagnosis, Differential
Disease-Free Survival
Giant Cell Tumors / diagnosis*,  pathology,  surgery
Histiocytoma, Benign Fibrous / diagnosis*,  pathology
Laryngeal Neoplasms / diagnosis*,  pathology,  surgery
Tomography, X-Ray Computed

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