Document Detail

Giant cell tumor of bone. Variations in patterns of appearance of different cell types.
MedLine Citation:
PMID:  218336     Owner:  NLM     Status:  MEDLINE    
Eleven benign giant cell tumors of bone were studied in the electron microscope, and the fine structural localization of acid phosphatase was elucidated. Three distinct cell types are always present in these tumors: stromal cells type 1; stromal cells type 2; and multinucleated giant cells. Small mononuclear cells may also occur, but are not likely to be actively participating in the neoplastic process. The range of variability in the fine structure of the different cell types constituting this tumor has been established. Variations in appearances include: a) presence of nuclear pseudoinclusions in stromal cells type 1 and multinucleated giant cells; b) aberrations in the structure of the rough surfaced endoplasmic reticulum in the same cell types; c) occurrence of ruffled borders, ectoplasmic layers and cytoplasmic labyrinths containing acid phosphatase in the giant cells. Some giant cells show evidence of marked phagocytic activity and contain large and numerous residual bodies carrying acid phosphatase. The significance of the interrelations between the different cell types are discussed and the possible role of stromal cells type 2 in immunological mechanisms directed against the tumor cells are mentioned.
T Aparisi; B Arborgh; J L Ericsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histology     Volume:  381     ISSN:  0340-1227     ISO Abbreviation:  Virchows Arch A Pathol Anat Histol     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-05-24     Completed Date:  1979-05-24     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  7505137     Medline TA:  Virchows Arch A Pathol Anat Histol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  159-78     Citation Subset:  IM    
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MeSH Terms
Acid Phosphatase / analysis
Bone Neoplasms / enzymology,  ultrastructure*
Endoplasmic Reticulum / ultrastructure
Giant Cell Tumors / enzymology,  ultrastructure*
Inclusion Bodies / ultrastructure
Lysosomes / ultrastructure
Microscopy, Electron
Middle Aged
Reg. No./Substance:
EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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