Document Detail

Giant cell myocarditis responding to immunosuppressive therapy.
MedLine Citation:
PMID:  10713027     Owner:  NLM     Status:  MEDLINE    
An unusual case of giant cell myocarditis presenting with cardiogenic shock that dramatically responded to conventional dose of steroids and azathioprine is reported. Cardiac recovery was rapid, complete (left ventricular ejection fraction rose to 55% from 10%), and was accompanied by the disappearance of the inflammatory infiltrates including giant cells in the control endomyocardial biopsy. Maintenance of the recovery at 16 months of follow-up on a low dose of azathioprine suggests that giant cell myocarditis might be a heterogeneous disease having either a negative untreatable trend necessitating cardiac transplantation, or a curable substrate responding to immunosuppressive drugs.
A Frustaci; C Chimenti; M Pieroni; N Gentiloni
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  117     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-04     Completed Date:  2000-04-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  905-7     Citation Subset:  AIM; IM    
Departments of Cardiology, Catholic University, Rome, Italy.
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MeSH Terms
Azathioprine / therapeutic use
Drug Administration Schedule
Drug Therapy, Combination
Endocardium / pathology
Giant Cells* / pathology
Immunosuppressive Agents / therapeutic use*
Macrophages / pathology
Myocarditis / drug therapy*,  pathology
Myocardium / pathology
Prednisolone / therapeutic use
Prednisone / therapeutic use
Shock, Cardiogenic / drug therapy,  pathology
Ventricular Dysfunction, Left / drug therapy,  pathology
Reg. No./Substance:
0/Immunosuppressive Agents; 446-86-6/Azathioprine; 50-24-8/Prednisolone; 53-03-2/Prednisone

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