Document Detail


Giant cell interstitial pneumonia in a 15-year-old boy.
MedLine Citation:
PMID:  12487179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Giant cell interstitial pneumonia (GIP) is a very uncommon respiratory disease. We report a juvenile patient with GIP aged 15 years. Although he has a negative past history of direct exposure to hard metals, we could not exclude possible exposure in very small amounts through his parents. Microscopic examination of lung biopsy specimen obtained by video-assisted thoracoscopy revealed marked cellular interstitial infiltrates and prominent intraalveolar macrophages as well as giant cells showing cellular cannibalism. Analysis of the biopsied lung tissue for cobalt and tungsten was negative. Clinical symptoms, laboratory, and radiological findings improved markedly after treatment with corticosteroids. To our knowledge, only eleven cases of GIP have been reported in Japan. Although possible exposure to hard metals was identified in 9 of the 11 reported cases, there is no clear dose-dependent relationship with onset and prognosis. The average age at onset was 46.2+/-15.0 years. Our patient is the youngest case of GIP reported in the world.
Authors:
Tomoyuki Kakugawa; Hiroshi Mukae; Towako Nagata; Hiroshi Ishii; Hideyuki Kaida; Tomayoshi Hayashi; Takashi Suematsu; Jun-ichi Kadota; Shigeru Kohno
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  41     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-12-18     Completed Date:  2003-09-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1007-12     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Giant Cells*
Humans
Lung Diseases, Interstitial / pathology*
Male

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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