| Giant cell arteritis: a systemic vascular disease. | |
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MedLine Citation:
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PMID: 18593802 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Giant cell arteritis (GCA) is increasingly being recognized as a systemic vascular disease, not confined to the cranial arteries. Epidemiological studies have shown that almost one-third of the patients with GCA develop serious peripheral vascular complications during long-term follow up, and there is growing evidence that unrecognized extracranial involvement may be even more common. GCA of large- and medium-sized peripheral arteries typically leads to long tapering and occlusion of the arterial lumen due to concentric intimal thickening, sometimes accompanied by spontaneous dissection. Depending on the extent of the arterial obliteration and on the anatomy of the involved arterial segment, this may result in severe ischemia of the limbs during the acute phase of the disease. GCA of the aorta usually remains asymptomatic for many years, and leads to a markedly increased risk of aneurysms and dissections, particularly of the thoracic aorta. Evolving vascular imaging techniques such as duplex ultrasound, computer tomography (CT), magnetic resonance imaging (MRI), and fluorine-18-desoxyglucose positron emission tomography (18F-FDG-PET) have greatly improved our ability to detect and study arterial changes in large-artery vasculitis. Boosted by these advances in vascular imaging, vascular specialists are increasingly involved in the early diagnosis, follow-up and treatment of patients with large-vessel vasculitis. |
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Authors:
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Federico Tatò; Ulrich Hoffmann |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Vascular medicine (London, England) Volume: 13 ISSN: 1358-863X ISO Abbreviation: Vasc Med Publication Date: 2008 |
Date Detail:
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Created Date: 2008-07-02 Completed Date: 2008-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
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Languages: eng Pagination: 127-40 Citation Subset: IM |
Affiliation:
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Division of Vascular Medicine, Ludwig Maximilians University Hospital, Pettenkoferstrasse 8a, D-80336 [corrected] Munich, Germany. Federico.Tato@t-online.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiography, Digital Subtraction Arterial Occlusive Diseases / epidemiology, metabolism, pathology*, therapy Biological Markers / blood Cardiovascular Agents / therapeutic use Fluorodeoxyglucose F18 / diagnostic use Giant Cell Arteritis / epidemiology, metabolism, pathology*, therapy Glucocorticoids / therapeutic use Humans Inflammation Mediators / blood Magnetic Resonance Angiography Peripheral Vascular Diseases / epidemiology, metabolism, pathology*, therapy Physical Examination Positron-Emission Tomography Radiopharmaceuticals / diagnostic use Tomography, X-Ray Computed Treatment Outcome Ultrasonography, Doppler, Color Vascular Surgical Procedures |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cardiovascular Agents; 0/Glucocorticoids; 0/Inflammation Mediators; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Erratum In:
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Vasc Med. 2008 Aug;13(3):299 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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