| Giant cell arteritis and polymyalgia rheumatica: are pregnancies a protective factor? A prospective, multicentre case-control study. GRACG (Groupe de Recherche sur l'Artérite à Cellules Géantes). | |
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MedLine Citation:
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PMID: 10342623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the potential role of allo-immunization, either by former pregnancies, or by a history of blood transfusion, in the pathogenesis of giant cell arteritis and polymyalgia rheumatica. METHODS: Two hundred and eighty-five incident female cases and 186 age-matched, population-based female controls were prospectively included in a multicentre case-control study. RESULTS: The number of pregnancies was significantly lower in cases than in controls (nulliparous: 21.55% vs 12.90%; > or =4 pregnancies: 16.25% vs 27.42%; Wilcoxon rank sum test: P = 0.0019) in biopsy-proven or negative temporal arteritis and, to a lesser extent, in polymyalgia rheumatica. No difference was found for history of blood transfusion. Pregnancies remained negatively associated with the disease in a multivariate analysis including cardiovascular risk factors such as smoking or a pre-existing peripheral vascular disease. CONCLUSION: Former pregnancies are not a risk factor for giant cell arteritis. Pregnancies may be protective thanks to an effect of the associated hyperoestrogenic state against alterations of the artery wall, as suggested in animal models. |
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Authors:
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P Duhaut; L Pinède; S Demolombe-Ragué; C Dumontet; J Ninet; D Seydoux; R Loire; J Pasquier |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 38 ISSN: 1462-0324 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-06-10 Completed Date: 1999-06-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 118-23 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Edouard Herriot Hospital, Lyon, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiovascular Diseases / complications Case-Control Studies Female Giant Cell Arteritis / etiology*, physiopathology Humans Middle Aged Polymyalgia Rheumatica / etiology*, physiopathology Pregnancy* Prospective Studies Risk Factors Smoking / adverse effects |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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