Document Detail


Giant cell arteritis incidence: analysis by season and year in mid-Atlantic United States.
MedLine Citation:
PMID:  23332080     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Evaluate the incidence of biopsy-proven giant cell arteritis (GCA) for seasonal or annual variability from a tertiary care center in the Mid-Atlantic United States. DESIGN: Retrospective chart review of all patients seen in the Neuro-Ophthalmology Service undergoing temporal artery biopsy (TAB) from 1994 to 2011. PARTICIPANTS: The charts of 744 patients were reviewed and 215 patients were diagnosed with GCA based on positive TAB results. METHODS: All results between 1994 and 2011 were reviewed. GCA incidence data was evaluated by year, season, and month for any trends or cyclic patterns. A subset of clinical charts was reviewed to determine time from symptoms to diagnosis. MAIN OUTCOME MEASURE: Incidence of biopsy proven GCA. RESULTS: The majority of patients were female (74%) and over the age of 60 (98.6 %). The diagnosis of biopsy-proven GCA was found in 215 of 744 (28.9%) patients. The incidence of biopsy proven GCA by year varied, with the peak incidence in 1996. The monthly incidence peaked in July and had a trough in October. However, Poisson regression analysis did not show any statistically significant trend over time or cyclic pattern to the incidence by year, season, or month. CONCLUSION: The incidence of biopsy-proven GCA in the population studied did not have any significant cyclic pattern over the last 17 years. The highest incidence by month was noted in July with a trough in October. However, this was not a significant pattern by month or season to support infectious or periodic environmental factors inciting GCA.
Authors:
Krystian Kisza; Ann P Murchison; Yang Dai; Jurij R Bilyk; Ralph C Eagle; Robert Sergott; Peter J Savino
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  -     ISSN:  1442-9071     ISO Abbreviation:  Clin. Experiment. Ophthalmol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Clinical and Experimental Ophthalmology © 2013 Royal Australian and New Zealand College of Ophthalmologists.
Affiliation:
Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.
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