Document Detail

Giant cell arteritis: diagnosing and treating inflammatory disease in older adults.
MedLine Citation:
PMID:  16092890     Owner:  NLM     Status:  MEDLINE    
Giant cell arteritis (GCA), also known as temporal arteritis, cranial arteritis, or granulomatous arteritis, is a systemic necrotizing vasculitis seen in patients typically over age 50. If untreated, GCA can cause permanent visual loss in one or both eyes in 13% to 50% of patients. Primary care physicians routinely see elderly patients with headaches and fatigue; these may be potential symptoms of GCA. C-reactive protein (CRP) in conjunction with erythrocyte sedimentation rate (ESR) has 97% specificity in diagnosing GCA. Temporal artery biopsy confirms the diagnosis in many cases. Early recognition and treatment of this potentially blinding condition is thus essential. Systemic steroids are the standard therapy for patients with a positive diagnosis of GCA, and in a high percentage of patients the treatment may extend for more than one year.
Syed S Azhar; Rosa A Tang; E Ulysses Dorotheo
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Geriatrics     Volume:  60     ISSN:  0016-867X     ISO Abbreviation:  Geriatrics     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-11     Completed Date:  2005-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985102R     Medline TA:  Geriatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  AIM; IM    
Department of Family Medicine, University of Texas Medical Branch, Galveston, TX, USA.
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MeSH Terms
Giant Cell Arteritis / classification,  diagnosis*,  drug therapy*
Glucocorticoids / therapeutic use
Middle Aged
Optic Neuropathy, Ischemic / diagnosis
Physical Examination
Prednisolone / therapeutic use
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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