Document Detail

Giant bilateral renal angiomyolipomas and lymphangioleiomyomatosis presenting after two successive pregnancies successfully treated with surgery and rapamycin.
MedLine Citation:
PMID:  22125460     Owner:  NLM     Status:  MEDLINE    
We report the case of a 25-year-old woman who presented with abdominal and flank pain with two successive pregnancies and was diagnosed of giant bilateral renal AMLs and pulmonary LAM associated with TSC in the post-partum of her second pregnancy. This case illustrates that in women with TSC rapid growth from renal AMLs and development of LAM may occur with successive pregnancies. It also stresses the potential for preservation of renal function despite successive bilateral renal surgery of giant AMLs. Moreover, the treatment with a low-dose rapamycin may be an option for LAM treatment. Finally, a low-dose rapamycin may be considered as an adjuvant treatment together to kidney-sparing conservative surgery for renal AMLs.
Ramón Peces; Emilio Cuesta-López; Carlos Peces; Rafael Selgas
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-02
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  11     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-29     Completed Date:  2012-03-27     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  England    
Other Details:
Languages:  eng     Pagination:  2115-23     Citation Subset:  IM    
Servicio de Nefrología, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, Spain.
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MeSH Terms
Angiomyolipoma / complications,  drug therapy,  surgery,  therapy*
Kidney Neoplasms / complications,  drug therapy,  surgery,  therapy*
Lymphangioleiomyomatosis / complications,  drug therapy,  surgery,  therapy*
Pregnancy Complications, Neoplastic / drug therapy,  surgery,  therapy*
Sirolimus / therapeutic use*
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:

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